Adaptive Biotechnologies Announces New Translational Collaboration to Measure Minimal Residual Disease with clonoSEQ Assay Across BeiGene’s Lymphoid Malignancy Pipeline

• Data generated by Adaptive’s next-generation sequencing-based MRD assay will support the development and commercialization of investigational medicines for hematologic malignancies
  

SEATTLE, Nov. 07, 2023 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (Nasdaq: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced a multi-year, global translational collaboration with BeiGene to assess minimal residual disease (MRD) using clonoSEQ assay technology across the company’s pipeline of treatments for patients with lymphoid malignancies.

“Adaptive is pleased to partner with BeiGene to support the clinical development and potential regulatory approval of their investigational therapies in lymphoid malignancies,” said Mary Pat Lancelotta, Senior Vice President, BioPharma at Adaptive Biotechnologies. “MRD status has strong prognostic value, and by integrating the measure into clinical studies our partners can more quickly and efficiently evaluate and advance novel therapeutics.”

MRD assessment is playing a growing role in clinical trials for lymphoid malignancies by providing an early measure of treatment response and serving as a potential endpoint, which may enable novel therapies to be made available to patients sooner. As the first and only standardized test authorized by the U.S. Food and Drug Administration (FDA) for MRD assessment in bone marrow from patients with multiple myeloma or B-cell acute lymphoblastic leukemia (B-ALL) and blood or bone marrow from patients with chronic lymphocytic leukemia (CLL), Adaptive’s clonoSEQ assay technology is the test of choice among drug developers. It has been included in global, label-enabling studies for a multitude of therapies approved over the past several years and is also now widely adopted in the clinic. It is used at all 33 National Comprehensive Cancer Network (NCCN) centers, and as data supporting its clinical utility mount, its use is also growing in the community setting.

This multi-year agreement will cover existing and future programs and adds to Adaptive’s growing list of translational collaborations with biopharmaceutical companies. As part of the collaboration, MRD status based on Adaptive’s clonoSEQ assay may be used as an endpoint in certain clinical trials to assess the depth and duration of response to BeiGene’s investigational medicines in patients with lymphoid malignancies. Adaptive will receive an upfront payment and will be eligible to receive future milestone payments upon achievement of specific regulatory milestones in certain geographies. Specific financial terms of the agreement will not be disclosed.