Arrowhead Presents New Phase 2 Data on Plozasiran and Zodasiran at AHA 2023 - Seite 2

TEAEs reported to date reflect the comorbidities and underlying conditions of the study population. Most serious TEAEs recovered with no sequelae.

Details about the AHA presentations are listed below.

Title: ARO-APOC3, an Investigational RNAi Therapeutic, Silences APOC3 and Reduces Triglycerides to Near Normal Levels in Patients With Severe Hypertriglyceridemia: SHASTA-2 Study Results
Date/Time: November 13, 2023, 9:45 a.m. EST
Presenter: Daniel Gaudet
Session: Lipid Lowering via Novel Pathways

Title: ARO-APOC3, an Investigational RNAi Therapeutic, Silences APOC3 and Reduces Atherosclerosis-Associated Lipoproteins in Patients With Mixed Dyslipidemia: MUIR Study Results
Date/Time: November 13, 2023, 1:30 p.m. EST
Presenter: Christie M Ballantyne
Session: Emerging Approaches to Lipid Lowering

Zodasiran Data

In the Phase 2 ARCHES-2 study of zodasiran in 204 subjects with mixed dyslipidemia who had fasting TGs between 150-499 mg/dL and either LDL-cholesterol greater than 70 mg/dL or non-HDL-cholesterol greater 100 mg/dL, two doses of 50 mg, 100 mg, or 200 mg of zodasiran once every 12 weeks silenced the expression of angiopoietin-like protein 3 (ANGPTL3) and decreased atherogenic lipoproteins. Treatment with zodasiran resulted in substantial reductions of ANGPTL3 up to -71% at week 8, TGs up to 59% at week 16, and LDL-C up to -32% at week 16.

ARO-ANG3 was also associated with a relative reduction in liver fat fraction at week 24, with no adverse events related to liver function test changes reported to date. ARO-ANG3 TEAEs reported to date are consistent with those expected in this patient population and with associated underlying comorbidities.

Details about the AHA presentation are listed below.

Title: ARO-ANG3, an Investigational RNAi Therapeutic, Silences the Expression of ANGPTL3 and Decreases Atherogenic Lipoproteins in Patients With Mixed Dyslipidemia: ARCHES-2 Study Results
Date/Time: November 13, 2023, 1:30 p.m. EST
Presenter: Robert S Rosenson
Session: Emerging Approaches to Lipid Lowering

Virtual Analyst and Investor Event

The company is hosting a virtual analyst and investor event today, November 13, 2023, at 4:30 pm ET featuring key opinion leaders who will discuss the plozasiran data and its potential as a treatment for SHTG and mixed dyslipidemia in patients with ASCVD. To register for the event, please visit: https://lifescievents.com/event/arrowhead/.