CENTOGENE and the Laboratory of Human Genetics of Infectious Diseases at Institut Imagine Announce Rare Disease Research Collaboration - Seite 2

With more than 350 million people worldwide affected by over 7,000 rare diseases, approximately 95% of which do not have an available treatment, rare disease patients are facing some of the highest unmet medical needs. Progress towards the development of new therapies and cures in rare diseases is hindered by several factors:

• A lack of disease understanding compounded by small patient population
• Difficulties in correctly diagnosing and identifying patients for trials
• A lack of clearly defined clinical endpoints
• Complexities around leveraging real-world data

By combining expertise, the collaboration will support end-to-end, data-driven drug discovery and clinical development to enable better health outcomes for rare disease patients.

“Since its creation in 2007, Institut Imagine has been forming partnerships with the leading healthcare players to combine resources and transform care for patients around the world,” said Stanislas Lyonnet, Director of Institut Imagine. “Institut Imagine is excited to see this partnership between the Laboratory of Human Genetics of Infectious Diseases and CENTOGENE to advance research and make an impact for patients for years to come.”

Dr. Vivien Béziat, Researcher at the Laboratory of Human Genetics of Infectious Diseases, and Dr. Christian Ganoza, Senior Scientist at CENTOGENE, are project leads for this collaboration.

About Institut Imagine

Located on the campus of the Necker-Enfants malades hospital, the Institut Imagine is a world leader in research, care and teaching on genetic diseases. Its unique architecture, designed by Jean Nouvel and Bernard Valéro, brings together 1,000 researchers, physicians, teacher-researchers, engineers and health care personnel in a single location to work with patients, with the ambition of accelerating research and diagnosis and therapeutic innovation to change the lives of families affected by genetic diseases. The Institut Imagine has been certified “Institut hospitalo universitaire” (IHU), in 2011 and 2019 and a “Institut Carnot”, in 2020. It is supported by six founding members, including AP-HP, Inserm and Université Paris Cité, as well as by private partners and patrons. Every day in France, 64 babies are born with a genetic disease. Nearly 8,000 genetic diseases affect more than 3 million people, of which nearly one in two is undiagnosed and more than 8 in 10 have no dedicated treatment. Faced with this public health emergency, the challenge is twofold: to diagnose and to cure.