Celularity’s Tri-layer Decellularized, Dehydrated Human Amniotic Membrane Product Investigated as a Carrier of Induced Pluripotent Stem Cell Derived-Limbal Stem Cells in the Treatment of Severe Ocular Surface Disease - Seite 2

Anna Gosiewska, PhD., Vice President of Research and Development for Degenerative Diseases, leading Celularity’s development of advanced biomaterials and cell technologies, stated, “The investigation into the integration of placental biomaterials into regenerative cellular medicine protocols may enhance the efficacy of stem cell therapies expanding the scope of potential applications, from treating degenerative diseases to repairing damaged tissues and organs. As our research continues to explore the remarkable capabilities of placental biomaterials combined with cell-based technologies, we believe we can accelerate the translation of discoveries from the laboratory to the clinic, bringing our innovative solutions to patients.”

The Gluck Tissue Engineering Laboratory is part of the Wilson College of Textiles at North Carolina State University and is focused on understanding how the microenvironment contributes to stem cell differentiation and function. Its Tissue Engineering Lab Team is particularly interested in corneal tissue engineering, focusing primarily on ocular surface regeneration. As noted by Dr Jessica M. Gluck, Principal Investigator of the Gluck Lab, “Working with Celularity provides a collaborative effort of moving ocular regenerative medicine closer to the clinic.”

The study described in the poster presentation concluded that tri-layer decellularized, dehydrated human amniotic membranes have the potential to be a viable carrier for iPSC-LSCs for the treatment of LSCD and other ocular surface disorders. The off-the-shelf availability of existing commercial tri-layer decellularized, dehydrated human amniotic membrane products, in combination with iPSC-LSCs, may improve patient access to LSCD treatment and the therapeutic management of LSCD.

The abstract authors are Nasif Mahmood (principal author), Daxian Zha, Dr. Brain C. Gilger, and Dr. Jessica M. Gluck, all of North Carolina State University; and Dr. Anna Gosiewska, Dr. Stephen A. Brigido, Dr. Robert J. Hariri, all of Celularity.

About Celularity

Celularity is a cellular and regenerative medicine company developing “off-the-shelf” placental-derived allogeneic cellular therapy product candidates, including T cells engineered with a chimeric antigen receptor (“CAR”), unmodified natural killer (“NK”) cells and genetically modified CAR NK cells, and mesenchymal-like adherent stromal cells (“MLASCs”). These therapeutic candidates target indications across a range of degenerative disorders and diseases including those associated with aging, which is known to be a major risk factor across multiple therapeutic areas including cancer, regenerative medicine, and immune disorders. Celularity also develops, manufactures, and markets advanced biomaterial products derived from the postpartum placenta and the umbilical cord and operates a commercial biobanking service. Celularity believes that by harnessing the placenta’s unique biology and ready availability, it is able to develop solutions that address a significant unmet global need for effective, accessible, and affordable therapeutics.