Foghorn Therapeutics to Present New Preclinical Data at 2024 AACR Annual Meeting, Reflecting Advances with Multiple Potential First-in-Class Medicines, Including the Selective Inhibitor of BRM, FHD-909 - Seite 2

Presentation Details

FHD-909

Poster Title: Discovery of selective BRM (SMARCA2) ATPase inhibitors for the treatment of BRG1 (SMARCA4) mutant cancers
Session: Experimental & Molecular Therapeutics
Poster Number: 3230 / 14
Session Date/Time: Monday, April 8, 1:30 p.m. – 5 p.m.
Presenter: Janice Lee, Director, Biology, Foghorn Therapeutics

CBP and EP300 Programs

Oral Presentation Title: Targeting Chromatin Regulatory Cancer Drivers with Degraders
Symposium Session: SY12 - Molecular Glues, PROTACs, and Next-Gen Degraders: Discovery and Early Preclinical Advances
Session Date/Time: Tuesday, April 9, 10:15 a.m. – 11:45 a.m.
Presenter: Steve Bellon, Chief Scientific Officer, Foghorn Therapeutics

Town Hall Title: Inhibit or Degrade?
Symposium Session: TM04 – Losing our inhibitions – is (protein) degradation preferred?: A chemistry in Cancer Research Working Group Town Hall Meeting
Session Date/Time: Monday, April 8, 6:00 p.m. – 8 p.m. Presenter: Laura La Bonte, Senior Director, Biology, Foghorn Therapeutics

Poster Title: Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications
Session: Experimental & Molecular Therapeutics
Poster Number: 6067 / 26
Session Date/Time: Tuesday, April 9, 1:30 p.m. – 5 p.m.
Presenter: Darshan Sappal, Director, Biology, Foghorn Therapeutics

Poster Title: Discovery of potent and selective EP300 degraders with anti-cancer activity 
Session: Experimental & Molecular Therapeutics
Poster Number: 6064 / 23
Session Date/Time: Tuesday, April 9, 1:30 p.m. – 5 p.m.
Presenter: Mark Zimmerman, Principal Scientist, Biology, Foghorn Therapeutics

FHD-609

Poster Title: Long acting injectable FHD-609 micro-suspension: A potent BRD9 degrader with comparable efficacy, reduced frequency of dosing in preclinical models
Session: Experimental & Molecular Therapeutics
Poster Number: 7185 / 26
Session Date/Time: Wednesday, April 10, 9 a.m. – 12:30 p.m.
Presenter: Mei Yun Lin, Senior Scientist, Pharmacology, Foghorn Therapeutics

The presentation and the posters will be accessible under the Science section of the Company’s website after the conference.

About FHD-909

FHD-909 (a.k.a. LY4050784) is a highly potent, allosteric and orally available small molecule that selectively inhibits the ATPase activity of BRM (SMARCA2) over its closely related paralog BRG1 (SMARCA4), two proteins that are the catalytic engines across all forms of the BAF complex, one of the key regulators of the chromatin regulatory system. In preclinical studies, tumors with mutations in BRG1 rely on BRM for BAF function. FHD-909 has shown significant anti-tumor activity across multiple BRG1-mutant lung tumors.