Late-Breaking Presentation at American Academy of Dermatology 2024 Annual Meeting Shows that JNJ-2113, the First and Only Investigational Targeted Oral Peptide, Maintained Skin Clearance in Moderate-To-Severe Plaque Psoriasis Through One Year - Seite 2

In FRONTIER 2, JNJ-2113 maintained high rates of skin clearance through 52 weeks in adults with moderate-to-severe plaque psoriasis. In the five JNJ-2113 treatment groups, response rates were maintained from Week 16 to Week 52 with the highest PASI 75 response observed in the 100 mg twice daily group (78.6% at 16 weeks and 76.2% at 52 weeks). Similar to the primary endpoint, responses were maintained through Week 52 for all five JNJ-2113 treatment groups for the key secondary endpoints of PASI 90 (59.5% at 16 weeks and 64.3% at 52 weeks), PASI 100 (40.5% at 16 weeks and 40.5% at 52 weeks), Investigator's Global Assessment (IGA) 0/1 (64.3% at 16 weeks and 73.8% at 52 weeks) and IGA 0 (45.2% at 16 weeks and 42.9% at 52 weeks).

A summary of PASI responder data from the FRONTIER 2 study at Week 52:

#	Cohort	PASI 75 (%)	PASI 90 (%)	PASI 100 (%)
1	25 mg daily (n=43)	48.8	27.9	14.0
2	25 mg twice daily (n=41)	58.5	36.6	17.1
3	50 mg daily (n=43)	69.8	41.9	20.9
4	100 mg daily (n=43)	65.1	51.2	25.6
5	100 mg twice daily (n=42)