OSE Immunotherapeutics Announces Peer-Reviewed Publication on Novel Myeloid Immune Checkpoint CLEC-1 in Journal of Immunology

OSE Immunotherapeutics Announces Peer-Reviewed Publication
on Novel Myeloid Immune Checkpoint CLEC-1
in Journal of Immunology

Nantes, France – April 2, 2024 – 7:30 am CET – OSE Immunotherapeutics SA (ISIN: FR0012127173; Mnemo: OSE) today announced the publication of novel data in the peer-reviewed Journal of Immunology ⁽¹⁾ on a first-in-class research program with CLEC-1, its novel myeloid immune checkpoint target for cancer immunotherapy.

The academic collaboration conducted with Dr Elise Chiffoleau’s team at the Center for Translational Research in Transplantation and Immunology ⁽²⁾ has led to the identification of CLEC-1 as a checkpoint, a receptor expressed by myeloid cells inhibiting key myeloid cell functions, and T-cell cross-priming and hence limiting anti-tumor immune responses. In the new publication, the collaborative research work confirmed and reinforced the potential of CLEC-1 as a novel myeloid immune checkpoint regulating acute immune responses.

The article, titled “CLEC-1 restrains acute inflammatory response and recruitment of neutrophils following tissue injury” concludes that CLEC-1 acts as an immune checkpoint for the control of acute immune response and restrains myeloid cell infiltration and associated inflammation.

Dr Elise Chiffoleau, INSERM scientist, said: “We are very pleased to have these novel research data published in “Journal of Immunology”, an internationally recognized scientific journal. Our collaborative work shows, for the first time, that CLEC-1 acts as an immune checkpoint for the control of acute immune responses in the context of sterile inflammation. Additionally, its pharmacological blockade with monoclonal antibodies can release breaks on innate immune responses involved in various type of diseases, in particular in immune responses against cancers.”

⁽¹⁾  CLEC-1 restrains acute inflammatory response and recruitment of neutrophils following tissue injury

Camille Ligeron*†1, Javier Saenz†1 1, Berangere Evrard†, Marion Drouin*†, Emmanuel Merieau†, Caroline Mary*, Kevin Biteau*, Emmanuelle Wilhelm*, Cécile Batty*, Vanessa Gauttier*, Irene Baccelli*, Nicolas Poirier*, Elise Chiffoleau†.
* OSE Immunotherapeutics, 22 Boulevard Benoni Goullin, Nantes, France.
† Nantes Université, Inserm, Centre de Recherche en Transplantation et Immunologie
Translationnelle, UMR 1064, ITUN, F-44000 Nantes, France

⁽²⁾  Collaborative academic program between OSE Immunotherapeutics and Dr Elise Chiffoleau’s research teams (Center for Research in Transplantation and Translational Immunology (CR2TI), UMR1064, INSERM, Nantes University at Nantes University Hospital, https://cr2ti.univ-nantes.fr/research/team-1).