Nuvectis Pharma's NXP900 Demonstrates Robust Activity in Non-Small Cell Lung Cancer Cell Lines

• Highly Synergistic Antiproliferative Activity in EGFR-resistant Cells in Combination with Osimertinib, the Active Ingredient in Tagrisso^TM
• Single Agent Antiproliferative Activity in Cells Resistant to Alectinib, the Active Ingredient in Alecensa^TM

Fort Lee, NJ, April 08, 2024 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) today recapped poster highlights from the 2024 American Association for Cancer Research (AACR) conference demonstrating highly synergistic antiproliferative activity in epidermal growth factor receptor (EGFR)-resistant non-small cell lung cancer (NSCLC) cells of NXP900 in combination with osimertinib, the active ingredient in Tagrisso^TM, an EGFR inhibitor approved for the treatment of NSCLC. The data reported, which confirms data previously published by the research team at Astra Zeneca, demonstrated that the combination reverses resistance to osimertinib versus osimertinib alone.

In addition, NXP900 demonstrated potent, single agent, antiproliferative activity in anaplastic lymphoma kinase (ALK)-resistant NSCLC cells and synergistic effects in combination with alectinib in alectinib sensitive cells. Alectinib is the active ingredient in Alecensa^TM, an ALK inhibitor approved for the treatment of NSCLC.

Moreover, effective inhibition of signaling pathways associated with osimertinib and alectinib resistance were observed in the respective cell lines tested.

Ron Bentsur, Chairman and Chief Executive Officer of Nuvectis, commented, “We are very pleased to be able to independently confirm the data previously published by the research team at Astra Zeneca, demonstrating the ability of NXP900 to reverse resistance to osimertinib in osimertinib resistant NSCLC cell lines, when administered in combination with osimertinib. We are also pleased with NXP900's potent single-agent activity in NSCLC cells resistant to alectinib.” Mr. Bentsur continued, “EGFR and ALK inhibitors, especially osimertinib and alectinib, have revolutionized the treatment paradigm in NSCLC. However, treatment resistance remains a major challenge in a considerable number of patients, and therefore inhibiting the key pathways associated with the development of EGFR and ALK resistance to restore cancer sensitivity to treatment represents significant potential in this disease.” Mr. Bentsur concluded, “With the NXP900 Phase 1a dose escalation study progressing as planned, we are excited about the potential opportunities presented by NXP900 in therapeutic areas of unmet medical need, both as a single agent and in combination with market-leading anticancer drugs such as Tagrisso, Alecensa and other approved drugs targeting EGFR and ALK-mutated tumors.”