Autonomix Announces Positive Findings from Preclinical Study Demonstrating Potential to Improve Renal Denervation

Preclinical study demonstrates potential of Autonomix technology to make renal denervation safer and more effective

Ongoing advancement of sensing and ablation technologies toward proof-of-concept clinical study

THE WOODLANDS, TX, April 09, 2024 (GLOBE NEWSWIRE) -- Autonomix Medical, Inc. (NASDAQ: AMIX) (“Autonomix” or the “Company”), a medical device company focused on advancing innovative technologies to revolutionize how diseases involving the nervous system are diagnosed and treated, today announced the successful completion of an animal study evaluating the Company’s proprietary catheter-based sensing technology for use in the renal artery.

The preclinical porcine model study was designed to assess the ability of the Company’s catheter-based sensing technology to effectively sense and target individual nerves surrounding the renal artery. For the study, epivascular injections of ethanol were given to target nerves and the Company’s sensing technology was successfully able to capture the down-regulated nerve signal of the treated nerve from within the renal artery, as well as the return to normal signal post ethanol treatment. These results strongly demonstrate the potential of Autonomix’s sensing technology to successfully locate nerves around the renal artery. These nerves include those responsible for regulating blood pressure and are the target of recently approved renal denervation procedures for hypertension.

Lori Bisson, Chief Executive Officer of Autonomix, commented, “Currently approved procedures using renal denervation for the treatment of hypertension involve ablating the general area where nerves are believed to exist without visibility of the actual nerves and without the ability to differentiate between those nerves causing hypertension and those serving other important functions. Essentially, they are treating blindly, without assurance of hitting the right target. The successful completion of this preclinical study provides us with confidence in the potential of our sensing technology to ultimately make renal denervation safer, faster, and more effective. While we are primarily focused on successful completion of our first in man study for pancreatic cancer pain, we are investigating exciting uses for the technology in other indications. We believe that based on our growing body of data, our technology may be able to address the significant unmet need for a tool that can successfully sense, target and influence neuronal signals safely and reliably across multiple indications, from pain to hypertension. We are committed to progressing the development of our technology forward with the goal of bringing benefit to patients in need.”