PHAXIAM Therapeutics announces enrolment of the first patient in the phase 1 study for the treatment of endocarditis infections caused by Staphylococcus aureus - Seite 2

These key data for PHAXIAM and wider for the development of phage therapy will be used to define the optimal intravenous administration method and will also be used for future efficacy studies of phage therapy in indications using this administration pathway. The first results of the study are expected during the 3^rd quarter of 2024.

Prof. Pascal Lim, Head of Cardiac Intensive Care at Hôpital Henri Mondor and Principal Investigator of the study, stated: "The treatment of endocarditis infection linked to S. aureus presents many challenges, and we are very pleased to take part in this study, which will evaluate phage therapy for the first time in this highly fatal condition. In this way, we hope to contribute to improving the treatment of patients who often face a therapeutic impasse.”

Thibaut du Fayet, Chief Executive Officer of PHAXIAM, concluded: "The inclusion of the first patient in the phase 1 study in endocarditis infection is a key step in our development strategy, which aims to provide phage therapy to patients suffering from diseases of high medical needs. The first results of this study, expected in Q3 2024, will enable us to analyse the safety and first efficacy signals of our anti-S. aureus phages with intravenous administration, in an indication where reducing mortality, which is still between 30% and 40%, is a major medical challenge. We look forward to these data, which, if positive, will give us a significant competitive advantage and will pave the way for the use of this administration route for our phages in other indications with significant unmet medical needs, such as bacteraemia.”

About PHAXIAM Therapeutics

PHAXIAM is a biopharmaceutical company developing innovative treatments for resistant bacterial infections, which are responsible for many serious infections. The company is building on an innovative approach based on the use of phages, natural bacterial-killing viruses. PHAXIAM is developing a portfolio of phages targeting 3 of the most resistant and dangerous bacteria, which together account for more than two-thirds of resistant hospital-acquired infections: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.

PHAXIAM is listed on the Euronext regulated market in Paris (ISIN code: FR0011471135, ticker: PHXM). PHAXIAM is part of the CAC Healthcare, CAC Pharma & Bio, CAC Mid & Small, CAC All Tradable, EnterNext PEA-PME 150 and Next Biotech indexes.

For more information, please visit www.phaxiam.com