Cognition Therapeutics Completes Enrollment in Phase 2 SHIMMER Study of CT1812 in Mild-to-Moderate Dementia with Lewy Bodies

- Top-line Results Expected in the Second Half of 2024 -

PURCHASE, N.Y., April 29, 2024 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc. (the “Company” or “Cognition”) (NASDAQ: CGTX), a clinical stage company developing drugs that treat neurodegenerative disorders, today announced that the company has reached target enrollment in the randomized, placebo-controlled Phase 2 SHIMMER (COG1201) study (NCT05225415), which is examining the safety and effectiveness of CT1812 in adults with mild-to-moderate dementia with Lewy bodies (DLB). Top-line results are expected in the second half of 2024 after the last participants have completed six months of treatment.

“There are currently no approved disease-modifying therapies for DLB, leaving people living with this disease in desperate need of treatment options,” Lisa Ricciardi, president and CEO of Cognition Therapeutics, stated, “The majority of patients with DLB have both Aβ and α-synuclein pathology. Because of our unique mechanism of action that targets both Aβ and α-synuclein oligomers, we believe that CT1812 may be able to slow the progression of disease.”

The SHIMMER study will assess safety and changes in cognition and executive function as measured by validated scales including the Montreal Cognitive Assessment (MoCA) and Cognitive Drug Research Battery (CDR) tools. In addition, biomarker evidence of disease modification and target engagement will be analyzed. Once available, the company anticipates reporting topline results in a press release and later presenting them at an appropriate medical meeting.

Ms. Ricciardi concluded, “I want to thank the patients, investigators and clinical partners who participated in SHIMMER. We look forward to analyzing the final results and reporting them later this year.”

About the SHIMMER Study
The SHIMMER study is a double-blind, placebo-controlled Phase 2 clinical trial designed to enroll 120 adults with mild-to-moderate DLB. Participants are evenly randomized to receive either placebo or one of two oral once-daily doses of CT1812 (100 mg or 300 mg) for six months. The SHIMMER study is supported by a grant award from the National Institute on Aging of the National Institutes of Health (NIH) totaling approximately $30 million and is being conducted in collaboration with James E. Galvin, MD, MPH, director of the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine and the Lewy Body Dementia Association (LBDA). The SHIMMER study is being conducted at over 30 sites in the United States, many of which are LBDA centers of excellence.