INmune Bio Inc. Provides Update on Two Patients from the Phase 1b Alzheimer’s Disease Trial who Continue to Receive XPro Under Compassionate Use for Over Three Years

Boca Raton, Florida, April 30, 2024 (GLOBE NEWSWIRE) --  INmune Bio Inc. (NASDAQ: INMB) (the “Company”), a clinical-stage immunology company focused on developing treatments that harness the patient’s innate immune system to fight disease, is pleased to share an update on two patients from the Phase 1b trial completed in 2021 who have continued to receive XPro for treatment of Alzheimer’s Disease (AD) for more than three years under the Australian compassionate use program known as the Special Access Scheme (SAS). 

Both patients, herein referred to as “Patient 1” and “Patient 2,” was an original study participant in the Phase 1b clinical trial (ClinicalTrials.gov ID NCT03943264), in the target dose 1mg/kg cohort, which commenced in November of 2019 and completed in September of 2021. 

In contrast to clinical trials, patients in the SAS receive exclusive care from their primary care physicians, with the Company's involvement limited to supplying XPro. Reports from the primary care physicians indicate that XPro has been well-tolerated throughout the treatment period, with stable cognitive function observed in the patients. Furthermore, the patients express a desire to continue receiving XPro for Alzheimer's disease treatment.

Patient 1 was diagnosed with AD at age 61 and enrolled in the Phase 1b clinical trial in December 2019 at age 63. Patient 1 completed the 3-month Phase 1b open label trial and opted to enroll in the 12-month open label extension. After completion of the open label extension, Patient 1 continued to receive XPro^TM under the SAS. The primary care physician treating Patient 1 under the SAS has indicated “[Patient 1] has suffered no obvious adverse reactions to XPro. His general physical state is unchanged. I believe that his mental cognitive state has also been stable with the use of XPro. His family members are keen to continue the management with XPro if available as they believe there is stability with the treatment.”

Patient 2 was diagnosed with AD at age 59 and enrolled in the Phase 1b clinical trial in December 2019 at age 60. Patient 2 completed the 3-month Phase 1b open label trial and opted to enroll in the 12-month open label extension. After completion of the open label extension, Patient 2 continued to receive XPro^TM under the SAS. The primary care physician treating Patient 2 under the SAS has indicated “[Patient 2’s] cognitive decline has stopped, and he continues to do well.”