Unleashing the Power of MAIT Cells

Pluri Launches Novel Immunotherapy Platform for Solid Tumor Cancer Treatment - Seite 2

When combined with Pluri's 3D cell expansion technology, the MAIT platform will enable commercial scale production of powerful immune cells as a potential first-in-class, ready to use, off-the-shelf therapy for cancer patients.

“Our MAIT platform is a culmination of two decades of innovation and scientific expertise, paving the way for a new era of effective immunotherapy,” said Yaky Yanay, CEO and President of Pluri. “We believe that our MAIT cells can make targeted, affordable and effective treatments readily accessible to all who need them. Our commitment extends beyond mere technological advancement; we aim to redefine what's possible in the fight against cancer.”

“Despite revolutionary progress in hematological malignancies, an equivalent success has yet to be duplicated in solid tumor malignancies, which present unique challenges. Pluri’s MAIT cells exhibit inherent biological advantages that may be pivotal in developing effective treatments for tough-to-treat cancers and solid tumors in particular,” said Dr. Arthur Machlenkin, PhD, Chief Scientific Officer of Pluri. “We are excited to continue developing these powerful cells into transformative therapies.”

Total Addressable Market

The global cancer immunotherapy market was valued at $100 billion in 2022 and expected to surpass around $275.11 billion by 2032, poised to grow at a compound annual growth rate (CAGR) of 10.70% from 2023 to 2032.

Leading Cancer Researchers Join Pluri’s Scientific Advisory Board

Understanding the potential of Pluri’s MAIT cells, two internationally recognized oncology researchers joined Pluri’s Scientific Advisory Board (SAB): Dr. Prasad S. Adusumilli and Dr. Richard L. Kendall.

Dr. Adusumilli, MD, is Professor and Deputy Chief, Thoracic Service; Vice Chair for Translational Research, Dept. of Surgery; Director, Mesothelioma Program; Min H. and Yu-Fan C. Kao Chair in Thoracic Cancers at Memorial Sloan Kettering Cancer Center (New York, NY). Research led by Dr. Adusumilli has focused on regional immunotherapy strategies, resulting in translation of mesothelin-targeted CAR T-cell immunotherapy for malignant pleural mesothelioma, lung, and breast cancers.

“I am excited to work with Pluri to develop scalable, engineered immune cells for cancer immunotherapy,” said Dr. Prasad S. Adusumilli. “The cells’ intrinsic ability to migrate to tumor sites can offer a beacon of hope in the fight against solid tumors, a significant unmet medical need.”