Charles River Launches Viral Vector Reference Materials to Streamline the Transition to GMP

Charles River Laboratories International, Inc. (NYSE: CRL) today announced the launch of its reference materials for adeno associated virus (AAV) and lentiviral vector (LVV) portfolio, designed to streamline Cell and Gene Therapy (CGT) research and development as it scales to Good Manufacturing Practice- (GMP) quality.

Moving towards a gold standard for reference materials, Charles River is introducing six AAV reference material serotypes, offering superior empty and full capsid ratios and high vector genome concentration (GC/mL), plus five LVV reference material products, available with different combinations of promoters and reporter genes. The additional reference materials add to the Company’s extensive portfolio of plasmid and viral vector contract development and manufacturing organization (CDMO) offerings, reinforcing its concept-to-cure commitment to CGT researchers and developers by enabling partners to navigate the path from early discovery to commercial.

ASGCT Launch
Charles River will officially launch its AAV and LVV reference materials with supporting case study data during the American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 7 – 11, 2024, in Baltimore, MD.

Meet the Charles River team at Booth #327 to discuss how to streamline the CGT research and development process, and explore various presentations and scientific posters from subject matter experts, including:

• A cross-functional research and discovery project showcasing AAV reference material data, AAV Cell Surface Target Profiling Using Binding and Functional Cell Microarray Screening Technology (#462), presented by Claire Tebbutt, Group Leader, Discovery
  • Wednesday, May 8, 12:00-7:00 p.m.: AAV Vectors – Virology and Vectorology (Exhibit Hall)
• Closed Automation Enables Quick Fill-Finish of Large-Scale T Cell Therapy While Maintaining Consistency and Quality of the Final Product (#867), presented by Min Sung Park, Process Development Scientist, Cell and Gene Therapy CDMO Services
  • Wednesday, May 8, 12:00-7:00 p.m.: Cell Therapy Product Engineering, Development, and Manufacturing (Exhibit Hall)
• Matrix Approach for Potency Assay Development of Cell and Gene Therapy Products: A Case Study for AAV Vectors (#1519), presented by Karen Doucette, Scientific Advisor, Cell and Gene Therapy CDMO Services
  • Friday, May 10, 12:00-7:00 p.m.: AAV Vectors - Product Development Manufacturing and Approval Considerations (Exhibit Hall)

To view the full list and to schedule a meeting, visit criver.com.