Omega Therapeutics Presents New Preclinical Data at ASGCT 2024 Demonstrating Tunable and Durable Upregulation of Gene Expression with Epigenomic Controllers

• Programmable epigenomic mRNA candidates enabled durable and robust upregulation of gene expression across a diverse set of gene types and regulatory mechanisms
• Additional OMEGA platform capabilities demonstrated, including reversible downregulation and multiplexed upregulation of gene expression

CAMBRIDGE, Mass., May 08, 2024 (GLOBE NEWSWIRE) -- Omega Therapeutics, Inc. (Nasdaq: OMGA) (“Omega”), a clinical-stage biotechnology company pioneering the development of a new class of programmable epigenomic mRNA medicines, today announced the presentation of new preclinical data demonstrating durable and tunable bidirectional regulation of gene expression in cellular models at the pre-transcriptional level at the American Society of Gene and Cell Therapy (ASGCT) 27^th Annual Meeting, taking place in Baltimore, Maryland, May 7 – 11.

“These exciting new data underscore the versatile capabilities and power of our OMEGA platform,” said Thomas McCauley, Ph.D., Chief Scientific Officer of Omega Therapeutics. “We have demonstrated preclinically that we can prospectively engineer epigenomic controllers to predictably and durably upregulate gene expression across a diverse range of gene types, including turning on inactivated genes, augmenting the expression of genes with low baseline expression levels, and leveraging existing genomic regulatory processes to boost expression. These capabilities unlock a wide spectrum of possibilities to apply precision epigenomic control as a novel therapeutic modality to meaningfully address key drivers of many diseases.”

Details for the poster presentation are as follows:

Title: Tuned Upregulation of Diverse Gene Targets Using Programmable Epigenomic Controllers
Abstract Number: 697
Poster Session: Epigenetic Editing and RNA Editing
Date and Time: May 8, 2024, from 12:00 p.m. – 7:00 p.m. ET

Key Findings

These preclinical findings demonstrate the ability of epigenomic controllers (ECs) to enhance target gene expression across various baseline levels of expression and cellular conditions, achieving up to a 10,000-fold increase in expression for inactivated gene targets and maintaining a stable 2-fold increase in expression for up to 55 days for another gene target. Additionally, simultaneous targeting of two regulatory elements for the same gene with two separate ECs yielded a synergistic effect, more than doubling expression compared to single element targeting.