Entero Therapeutics Presents Two Posters on Celiac Disease Research at the 2024 Digestive Disease Week (DDW) Conference

Presentations highlight new VCIEL scale to measure small intestinal mucosal health and research from rich database of latiglutenase Phase 2 clinical trials

BOCA RATON, Fla., May 20, 2024 (GLOBE NEWSWIRE) -- Entero Therapeutics, Inc., (NASDAQ: ENTO), (“Entero Therapeutics” or the “Company”), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases, yesterday presented two posters on celiac disease research at the 2024 Digestive Disease Week (DDW 2024) Conference in Washington, D.C. The presentations draw upon research from the robust clinical program investigating latiglutenase, an oral biotherapeutic being developed as a potentially first-in-class, targeted, oral biotherapeutic for celiac disease (CeD). The results from these presentations demonstrate potential for improved CeD diagnostics and clinical trial design.

“These findings will enable us to better monitor celiac disease and refine the tools we use in its diagnosis,” said Jack Syage, Ph.D., President and Chief Scientific Officer of Entero Therapeutics. “The data that indicates significantly higher levels of gluten are required to revert serology to positive in CeD patients underscores a fundamental gap in our diagnostic capabilities. This discovery, combined with the introduction of the VCIEL scale, offers a more nuanced approach to assessing mucosal health, ultimately enhancing the accuracy of our diagnostic criteria and paving the way for more effective targeted therapies.”

“This research is foundational to better understanding the triggers and intestinal damage of celiac disease through a quantitative lens,” stated James Sapirstein, Chief Executive Officer of Entero Therapeutics. “By quantifying the amount of gluten required to elicit an adverse immune response and measuring the underlying tissue alterations that lead to celiac symptoms, we can better design our phase 3 clinical trial and determine what constitutes meaningful change in disease severity in response to latiglutenase, our investigational therapeutic.”

The first presentation, titled, “A Composite Mucosal Scale for Celiac Disease Encompassing both Morphology and Inflammation,” highlights VCIEL, a novel quantitative composite scale, combining the histologic scales of villus height to crypt depth ratio (Vh:Cd) and density of intraepithelial lymphocytes (IEL). As there is currently no broadly accepted measure of mucosal injury, the VCIEL scale is designed to improve the sensitivity and accuracy of indicators measuring small intestinal mucosal health in CeD patients. As described in the poster, the VCIEL scale consistently showed improvements over the individual Vh:Cd and IEL measures across multiple studies, suggesting that VCIEL provides better statistical precision and may be more sensitive to histological changes than the traditional measures.