Medivation Highlights New Data From Differentiated Oncology Portfolio at ESMO 2016

SAN FRANCISCO, CA--(Marketwired - September 28, 2016) - Medivation, Inc. (NASDAQ: MDVN) today announced that new data from Company-sponsored and investigator-initiated clinical trials will be presented at the European Society for Medical Oncology (ESMO) 2016 Congress, being held October 7-11, in Copenhagen. Presentations include a pilot study of the company's investigational PARP inhibitor talazoparib in patients with BRCA-mutated breast cancer, and analyses of enzalutamide in the advanced prostate cancer setting, representing research advances in serious diseases for which there are limited options.

"We are excited to share data highlighting the clinical impact and potency of our potential best-in-class PARP inhibitor, talazoparib," said David Hung, M.D., founder, president and CEO of Medivation. "In addition, the breadth of enzalutamide data presentations shows our commitment to fully investigating its utility in patients with advanced prostate cancer."

Data presentations include:

Talazoparib: Investigational data demonstrating potential in BRCA-mutated breast cancer, for which there are no targeted treatment options:

• A pilot study of neoadjuvant talazoparib for early-stage breast cancer patients with a BRCA mutation [Abstract #153P; Saturday, October 8, 15:00 CEST]

Enzalutamide*: Updates on efficacy and safety, and additional analyses, in advanced prostate cancer:

• EMBARK: A Phase 3, randomized, efficacy and safety study of enzalutamide plus leuprolide, enzalutamide monotherapy, and placebo plus leuprolide in men with high-risk nonmetastatic prostate cancer progressing after definitive therapy [Abstract #770TiP; Sunday, October 9, 13:00 CEST]
• Prognostic factors in men with metastatic castration-resistant prostate cancer treated with enzalutamide or bicalutamide in TERRAIN [Abstract #759P; Sunday, October 9, 13:00 CEST]
• Efficacy and safety of enzalutamide plus androgen deprivation therapy vs placebo plus androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: the ongoing ARCHES trial [Abstract #767TiP; Sunday, October 9, 13:00 CEST]
• Efficacy and safety of enzalutamide vs placebo in chemotherapy-naïve patients with progressive metastatic castration-resistant prostate cancer following androgen deprivation therapy: an Asian multinational study [Abstract #749P; Sunday, October 9, 13:00 CEST]

* Enzalutamide is developed through a collaboration between Medivation and Astellas and commercialized under the brand name XTANDI^®.