TiGenix publishes transparency notifications pursuant to Article 14 of the Law of May 2, 2007

REGULATED INFORMATION
PRESS RELEASE

TiGenix publishes transparency notifications pursuant to Article 14 of the Law of May 2, 2007

Leuven (Belgium) - October 26, 2016, 20:00h CET - TiGenix NV (Euronext Brussels: TIG) announced today that it received two transparency notifications pursuant to Article 14, first paragraph of the Belgian Law of May 2, 2007 regarding the publication of major holdings in issuers whose securities are admitted to trading on a regulated market and including various provisions.

Summary of the notifications

On October 21, 2016, TiGenix NV received two transparency notifications from RA Capital Management, LLC. In the first transparency notification RA Capital Management, LLC notifies the acquisition of 7,500,000 voting rights linked to securities in TiGenix NV (3.71% of the total voting rights) on March 14, 2016. As a result, the 3% threshold was crossed upwards. In the second transparency notification, RA Capital Management, LLC notifies the subsequent disposal of voting rights linked to securities on September 29, 2016, after which it held 6,039,076 voting rights in TiGenix NV (2.99% of the total voting rights) as of September 29, 2016 and consequently crossed downwards the 3% threshold.

Content of the first notification

Date of the notification: October 14, 2016.

Reason of the notification: acquisition of voting securities or voting rights.

Person subject to the notification requirement: RA Capital Management, LLC (a person that notifies alone).

Date on which the threshold was crossed: March 14, 2016.

Threshold that was crossed: 3%.

Denominator: 202,304,587.

Details of the notification:

Following the acquisition of voting rights linked to securities, the number of voting rights is as follows:

• RA Capital Management, LLC holds 7,500,000 voting securities in TiGenix NV (3.71% of the total voting rights).

Chain of controlled undertakings through which the holdings are effectively held: RA Capital Management, LLC is not a controlled entity.

Additional information: RA Capital Management, LLC is the discretionary investment manager who exercises the voting rights.

Content of the second notification

Date of the notification: October 14, 2016.

Reason of the notification: disposal of voting securities or voting rights; downward crossing of the lowest threshold.

Person subject to the notification requirement: RA Capital Management, LLC (a person who notifies alone.

Date on which the threshold was crossed: September 29, 2016.