Lumos Pharma Announces New Data and Analysis of 15 Subjects from OraGrowtH212 Trial Presented at the 2023 ESPE Annual Meeting

• Deconvolution Analysis Shows 60% Increase in GH Secretion, Comparable to Established Values in Normal Children
• Analysis Shows Annualized Height Velocity Increased ~62% Compared to Baseline
• Data Support LUM-201 Mechanism of Action in Moderate PGHD Patient Population
  

AUSTIN, Texas, Sept. 26, 2023 (GLOBE NEWSWIRE) -- Lumos Pharma, Inc. (NASDAQ:LUMO), a biopharmaceutical company advancing an oral therapeutic candidate for moderate Pediatric Growth Hormone Deficiency (PGHD) through Phase 2 clinical trials, announced today that an analysis of interim data from its OraGrowtH212 Trial was given as an oral presentation at the 2023 annual meeting of the European Society for Paediatric Endocrinology (ESPE), held in The Hague, Netherlands, September 21-23, 2023.

“These new data and analysis of interim data from our OraGrowtH212 trial show that oral LUM-201 restored GH secretion to similar levels seen in normally growing children by enhancing endogenous pulsatile GH secretion while maintaining normal feedback control of IGF-1,” said John C. McKew, PhD, President and Chief Scientific Officer of Lumos. “The presented results add to the growing body of evidence supporting the physiologic mechanism of action for LUM-201, as well as its potential as a treatment for moderate PGHD. As we look ahead to our topline data readout from these trials in the fourth quarter, these results and the others we have released recently add to our confidence that at least one of the LUM-201 dose cohorts will meet growth expectations based on historical averages, and that the LUM-201 mechanism of action and potency can elicit sustained improvements in growth in the moderate PGHD patient population. We look forward to our topline data announcement and to continuing to advance our LUM-201 clinical program as potentially the first oral therapeutic for PGHD.”

The oral presentation, Deconvolution Analysis: Oral GH secretagogue (LUM-201) enhances growth in individuals with moderate Pediatric Growth Hormone Deficiency (PGHD) by enhancing endogenous GH secretion and increasing IGF-1 (Fernando Cassorla, MD, et al), was given in a late breaking session, Saturday, September 23, 9:30-10:30 AM CET (Local Time). The slides presented at ESPE are available on the Posters & Publications page under the Investors & Media section of Lumos Pharma’s website.