Phio Pharmaceuticals Announces Addition of Clinical Trial Sites at Banner MD Anderson Cancer Center, The George Washington University, and Integrity Research

--Four sites across the U.S. are now engaged in the Phase1b study

MARLBOROUGH, Mass., March 13, 2024 (GLOBE NEWSWIRE) -- Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a clinical stage biotechnology company whose proprietary INTASYL siRNA gene silencing technology is designed to make immune cells more effective in killing tumor cells, today announced the addition of three clinical trial sites for its Phase 1b study of PH-762:

• The George Washington University—Medical Faculty Associates in Washington, D.C.
• Banner MD Anderson Cancer Center in Gilbert, Arizona
• Integrity Research Clinical Associates in Delray Beach, Florida
  

These sites join Centricity Research in Dublin, Ohio, which enrolled the study’s first patient in November.

The principal investigator at the George Washington University trial is Vishal Patel, M.D. and Mark Gimbel, M.D. at the Banner MD Anderson Cancer Center trial site. Kevin Donnelly MD is principal investigator at Centricity Research.

“We are delighted to be able to include these sites, all of whom have an interest in immuno-oncology and an exceptional reputation in conducting trials in skin cancer,” said Robert Bitterman, CEO of Phio Pharmaceuticals. “Additionally, their inclusion expands our geographic reach facilitating broader patient inclusion in the clinical trial.”

PH-762 is an INTASYL compound that silences PD-1, a protein that inhibits T cells’ ability to kill cancer cells. The Phase 1b trial is a non-comparative study of neoadjuvant monotherapy using PH-762 in adult patients with cutaneous squamous cell carcinoma, melanoma, or Merkel cell carcinoma. The study is designed to evaluate the safety and tolerability of neoadjuvant use of intratumorally injected PH-762, assess the tumor response, and determine the dose or dose range for continued study of PH-762 in patients with cutaneous squamous cell carcinoma, melanoma, or Merkel cell carcinoma.

More information about this clinical trial is available at clinicaltrials.gov (identifier: NCT06014086).

About Phio Pharmaceuticals Corp.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) is a clinical stage biotechnology company whose proprietary INTASYL siRNA gene silencing technology is designed to make immune cells more effective in killing tumor cells. INTASYL is the only self-delivering RNAi technology focused on immuno-oncology therapeutics. INTASYL drugs precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems.