Alpine Immune Sciences Presents New Translational Data on Povetacicept at the European Lupus Meeting 2024 - Seite 2

 

19.0

Lung

0.49 ± 0.13

 

0.13 ± 0.05

 

3.8

Skin

2.7 ± 0.4

 

0.8 ± 0.2

 

3.4

Brain

0.10 ± 0.03

 

0.03 ± 0.01

 

3.3

 

Table 2: Molecular Attributes
Attribute		Povetacicept		Telitacicept
MW (kDa)1		62.6		75.3-75.42
pI1		6.5-7.0		7.1-8.4
KD, BAFF		59 pM		491 pM
KD, APRIL		1 pM		CNBD

1		Theoretical, calculated by Expasy (web.expasy.org/compute_pi/), Prot pI (Protpi.ch/Calculator/Protein Tool), or at Alpine based on Anal. Biochem 179:319 (1989).
2		MW reported as 80.24 kDa in J Clin Pharmacol 56:948 (2016)