Alios BioPharma Reports Positive Results of Its Anti-RSV Nucleoside Analog AL-8176 in a Phase 2 Challenge Study in Adults Infected With Respiratory Syncytial Virus (RSV) - Seite 2

"This is the first demonstration of potent antiviral effects for an RSV replication inhibitor and is an important milestone for patients suffering from this serious infection," stated Lawrence M. Blatt, PhD, President and Chief Executive Officer. "The positive data from this Phase 2 study for the treatment of RSV further demonstrates the progress that Alios has made toward our goal to develop therapies that address major respiratory viral infections where there are no effective treatment options."

About the RSV Human Challenge Study
The study was conducted at Retroscreen Virology's viral challenge unit in London, UK. The study utilized an adaptive design, enrolling up to 22 patients per quarantine, with a total of 62 patients enrolled across 3 quarantine periods. The patients were dosed twice daily (BID) for five days approximately 12 hours after subjects had a documented RSV infection (confirmed by PCR) or from the 6^th day after receiving the RSV challenge (whichever came first). 

About Respiratory Syncytial Virus (RSV)
RSV is a negative-sense, single-stranded RNA virus from the Paramyxoviridae family and is associated with significant morbidity in the US and mortality in the developing world. RSV is the most common cause of serious lower respiratory tract infections in infants, and is an important cause of lower respiratory tract infections in the immunocompromised and in adults with chronic pulmonary diseases such as asthma and COPD. As many as 68% of infants are infected during their first RSV season and nearly 100% of children contract the virus by their second or third year. Currently, there are no effective therapeutics available for treating RSV, limiting treatment to supportive care. RSV infections are also linked to later development of asthma in children. 

About AL-8176
AL-8176 is a nucleoside analog which is being developed by Alios BioPharma as an orally administered antiviral therapy for the treatment of infants infected with RSV. AL-8176 is designed to inhibit the replication of the RSV by acting on the viral polymerase. In vitro studies of the compound showed potent and highly selective inhibition of both RSV laboratory-adapted A and B strains as well as a range of diverse clinical isolates. Similar to other nucleoside analogs, AL-8176 demonstrates a high barrier to the development of viral resistance. 

About Alios BioPharma
Alios BioPharma is a clinical stage biopharmaceutical company in South San Francisco, CA that is developing novel antiviral therapies for the treatment of respiratory diseases. The Alios virology discovery and development platform consists of a proprietary chemical library of nucleoside analogs as well as novel, proprietary virology-based screening systems. Alios is developing a portfolio of potential therapeutics for viral infections including respiratory syncytial virus (RSV), influenza, rhinovirus and coronavirus. For more information please visit www.aliosbiopharma.com.

Alios BioPharma contact:
Bharath Kumandan
(Investors & Media)
650-635-5504
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