Dynavax Announces Upcoming Data Presentations for Three TLR9 Agonist Programs at the 2017 American Association for Cancer Research Annual Meeting
BERKELEY, CA--(Marketwired - March 20, 2017) - Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that it will be presenting data on three programs based on stimulation of the immune response using Toll-Like Receptor 9 (TLR9) agonists at the 2017 American Association for Cancer Research Annual Meeting in Washington, D.C. from April 1-5, 2017.
Dynavax is presenting data which summarizes the clinical responses and biomarker assessments from an ongoing Phase 1b/2 study investigating SD-101, Dynavax's intratumoral TLR9 agonist, in combination with KEYTRUDA® (pembrolizumab), an anti-PD-1 therapy developed by Merck (known as MSD outside the United States and Canada). The results provide insight into the immune mechanisms underpinning the activity of SD-101 and its effect on the tumor microenvironment.
Dynavax is also presenting preclinical data demonstrating significant anti-tumor activity of an inhaled TLR9 agonist in mice bearing lung tumors. This treatment highlights the synergy of the TLR9 agonist with anti-PD-1 leading to further reduction of both lung tumor burden and metastases in other organs along with long-term survival of treated mice. These studies provide the rationale for the development of DV281, a TLR9 agonist optimized for aerosol delivery. DV281, in combination with anti-PD-1 therapy, will enter clinical studies in non-small cell lung carcinoma patients later this year.
A third presentation shows that intratumoral vaccination with nanoparticles incorporating tumor antigen peptides and a TLR9 agonist provides anti-tumor immunity superior to conventional subcutaneous vaccination. Direct intratumoral vaccination using this novel vaccine platform and mode of administration significantly increases both the magnitude and functional activity of vaccine-primed cytotoxic T lymphocytes (CTL) and enhances control of metastatic disease.
The details of the poster presentations are as follows:
Pharmacodynamic changes confirm the mechanism of action mediating SD-101 efficacy, in combination with pembrolizumab, in a phase 1b/2 study in metastatic melanoma (MEL-01)
Abstract: | LB-239 | |
Category: | Late-Breaking Research: Clinical Research 2 / Endocrinology | |
Date/Time: | Tuesday, Apr 4, 1:00 p.m. to 5:00 p.m. ET | |
Location: | Poster section 34; Board number 5 | |
Development of an inhaled TLR9 agonist for the immunotherapy of lung cancer