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    Prana Biotech: PBT-2 - Die letzten 30 Beiträge

    eröffnet am 05.08.03 19:55:17 von

    neuester Beitrag 28.05.14 13:45:03 von
    Beiträge: 525
    ID: 761.658
    Aufrufe heute: 2
    Gesamt: 46.689

    Beitrag schreiben Ansicht: Die letzten 30 Beiträge
    schrieb am 28.05.14 13:45:03
    Beitrag Nr. 525 (47.061.150)
    Steht hier eine Übernahme an?

    Wenn man das US Board liest könnte es hier abgehen. Bin ich gespannt mit meinem Long Investment.

    Nur meine Meinung, keine Kauf- oder Verkaufsempfehlung.
    schrieb am 18.04.14 09:16:56
    Beitrag Nr. 524 (46.845.584)
    schade, war aber ein einkalkuliertes risiko... die krücken sind nu im arsch
    mal gut das mit 0,22 € der einstiegskurs nun nicht ganz so doll schmerzt.
    also kaufen schlafengehen und 10 jahre später mal schaun lol
    schrieb am 03.04.14 15:18:03
    Beitrag Nr. 523 (46.760.825)
    schrieb am 01.04.14 18:46:07
    Beitrag Nr. 522 (46.747.535)
    Antwort auf Beitrag Nr.: 46.746.781 von Finee am 01.04.14 17:10:13Traumtänzer Tanzi
    schrieb am 01.04.14 17:10:13
    Beitrag Nr. 521 (46.746.781)

    Dr. Rudy Tanzi ‏@RudyTanzi (vor 3 Std.)
    PBT2 misses primary endpoint in study of 40 Alzheimer's patients, but continues to be developed for Alzheimer's and Huntington's disease.
    schrieb am 01.04.14 12:12:34
    Beitrag Nr. 520 (46.744.341)
    Forum: ASX - By Stock

    "Let's not spin it. The result is a shock, the trial failed. Let's not spin it because the people who got it right for all the wrong reasons appear to have won. Let's not spin it because we have lost our money or our profits.

    Let's be sad for the people with, and the carers of people with, degenerative neurological conditions who have had their short term hopes for a genuine modifier of these conditions dashed.

    Hopefully, it is not the end of PBT2 as a potential treatment, but the road ahead is now longer and harder. Let's hope that the curse of AD and other neurological conditions, has suffered an irrecoverable dent from the efforts of the scientists and believers involved in this project. Let's hope that this unexpected setback is not the end, but another beginning in the fight for an effective treatment.

    Most of all let's hope that these results are analysed objectively. It is no good flogging a dead horse, but neither is it prudent to throw out the baby with the bath water.

    It has been a pleasure to read and contribute to this forum. Good luck to all those who gave their time and researched fairly and objectively over the years - there is no blame there.

    This result is the nature of the scientific method which, hopefully, will prevail in the end.
    schrieb am 01.04.14 09:42:09
    Beitrag Nr. 519 (46.743.049)
    EINE WUNDERSCHÖNE KATASTROPHE, aber das ist kein Weltuntergang!
    schrieb am 31.03.14 13:18:10
    Beitrag Nr. 518 (46.737.291)
    Leider ja ...

    Prana says drug fails Alzheimer's disease study…
    schrieb am 31.03.14 12:37:50
    Beitrag Nr. 517 (46.737.005)
    Schaut nicht so gut aus...
    schrieb am 31.03.14 09:38:48
    Beitrag Nr. 516 (46.735.647)
    Spannung steigt:

    Prana Biotechnology's (ASX: PBT, NASDAQ: PRAN) shares are in pre-open today, following the ASX granting the company a trading halt.

    The halt was granted pending results of its PBT2 IMAGINE Alzheimer’s Disease Phase II Trial.

    PBT's shares last traded at around $1, which is five times higher than a year ago.

    The halt will remain in place until the opening of trade on Wednesday 2nd April 2014, or earlier if an announcement was made to the market.
    schrieb am 21.03.14 19:26:34
    Beitrag Nr. 515 (46.676.935)
    Alzheimer-Forschung: Neue Ideen dringend gesucht


    Bislang sind alle Versuche gescheitert, Alzheimer zu heilen. Es kann sein, dass sie in die falsche Richtung gingen.…

    schrieb am 21.03.14 18:30:23
    Beitrag Nr. 514 (46.676.475)
    Heute übrigens dreifacher Hexensabbat an den Börsen...
    schrieb am 21.03.14 18:29:51
    Beitrag Nr. 513 (46.676.469)
    Antwort auf Beitrag Nr.: 46.674.065 von Finee am 21.03.14 13:39:28Hoffen wir, in die richtige Richtung - nach oben!

    schrieb am 21.03.14 13:39:28
    Beitrag Nr. 512 (46.674.065)
    Antwort auf Beitrag Nr.: 46.673.695 von Finee am 21.03.14 12:58:43Bitte anschnallen: Prana-Aktie vor dem Ausbruch!!!
    schrieb am 21.03.14 12:58:43
    Beitrag Nr. 511 (46.673.695)
    Antwort auf Beitrag Nr.: 46.672.745 von muellerei am 21.03.14 11:08:22PBT - PRANA BIOTECHNOLOGY LIMITED
    Course of Sales 21.03.2014
    Time (AEST) Price Volume Value
    18:47:01 1.239 416,552 516,107.93
    18:46:50 1.239 41,964 51,993.40
    18:46:35 1.239 115,545 143,160.26
    18:34:15 1.239 998,592 1,237,255.49
    18:04:30 1.240 294,210 364,820.40

    A very curious trade:
    18:03:08 3.718 574,06 2,134,358.80
    17:00:23 1.239 2,334,225 2,892,104.78 -> after hours
    16:10:44 1,2400 7.927.000 -> Schlusskurs
    15:59:39 1,2000 9

    schrieb am 21.03.14 11:29:46
    Beitrag Nr. 510 (46.672.909)
    schrieb am 21.03.14 11:08:22
    Beitrag Nr. 509 (46.672.745)
    Zitat von FruehrentnerGigantisches PRAN Handelsvolumen an der ASX am heutigen Freitag (ASX nun geschlossen, Australien ist bekanntlich unserer Uhrzeit voraus).

    Bei mir zeigt es die letzten 2 Tage dasselbe Handelsvolumen an.
    Oder liege ich falsch

    schrieb am 21.03.14 09:33:47
    Beitrag Nr. 508 (46.671.879)
    Gigantisches PRAN Handelsvolumen an der ASX am heutigen Freitag (ASX nun geschlossen, Australien ist bekanntlich unserer Uhrzeit voraus).
    schrieb am 20.03.14 21:48:33
    Beitrag Nr. 507 (46.669.569)
    Prana Biotechnology - A Gamble Worth Taking For Both Long- And Short-Term Investors

    March 20, 2014…
    schrieb am 17.03.14 21:12:13
    Beitrag Nr. 506 (46.647.067)

    heute morgen noch nachgelegt, und nun fast auf Tageshoch
    schrieb am 17.03.14 09:01:01
    Beitrag Nr. 505 (46.641.911)
    Antwort auf Beitrag Nr.: 46.641.841 von Finee am 17.03.14 08:54:08
    schrieb am 17.03.14 08:54:08
    Beitrag Nr. 504 (46.641.841)
    YAHOO Prana Biotechnology Limited Message Board

    superpisboy • 4 hours ago

    Fidelity The biggest Mutual Fund Holder in Prana and ICPT
    Fidelity has almost the same amount of shares in PRana as it does in ICPT, and in my opinion the Prana investment could surpass ICPT.

    Who Wins With Intercept?
    By Brendan Conway
    "The remarkable surge in Intercept Pharmaceuticals’ (ICPT) stock — 582% this year, at last check — appears to have delivered handy gains to some well-known Fidelity Investments mutual funds. But it may have just missed one of the firm’s most famous funds.
    The big winner appears to be Fidelity Select Biotechnology (FBIOX). This mutual fund owned a little over 1.31 million shares as of the end of November, a position valued at $68.9 million... "
    schrieb am 16.03.14 16:12:38
    Beitrag Nr. 503 (46.639.269)
    Antwort auf Beitrag Nr.: 46.638.809 von Finee am 16.03.14 13:24:22confirmed:…
    schrieb am 16.03.14 14:57:11
    Beitrag Nr. 502 (46.639.077)
    Und auch nicht zu vergessen:

    PRAN wird in Kürze in den ASX 300 aufgenommen:

    Prana Biotechnology (PRAN) is set to join the S&P/ASX 300 Index on March 21 following a quarterly review by Dow Jones.

    The S&P/ASX 300 is adjusted every quarter to reflect Australia's largest 300 companies by market cap. Dow Jone's decision comes after Prana's valuation surged to over $415M.
    Entrance to the S&P/ASX 300 will expose Prana to a wider range of investors.
    schrieb am 16.03.14 13:24:22
    Beitrag Nr. 501 (46.638.809)
    Kaum zu glauben:

    Fidelity bought 1m Prana shares

    Wikipedia: Fidelity Investments
    "Die FMR LLC (Fidelity Investments), häufig kurz Fidelity, ist ein US-amerikanisches Unternehmen der Finanzdienstleistungsbranche mit Stammsitz in Boston, Massachusetts. Das Unternehmen ist einer der größten Vermögensverwalter der Welt..."
    schrieb am 07.03.14 21:20:50
    Beitrag Nr. 500 (46.588.085)
    Eins steht fest:

    im März kommen die P-II Alzheimer Ergebnisse - ein binärer Event für Prana!
    schrieb am 07.03.14 21:19:27
    Beitrag Nr. 499 (46.588.077)
    U.a. mit Beitrag über Prana:

    March 07, 2014

    Alzheimer's Research Stocks - Technical And Other Considerations…
    schrieb am 07.03.14 09:21:05
    Beitrag Nr. 498 (46.581.695)
    Shining a Light on Overlooked and Underfollowed Biotechs: George Zavoico

    Source: George S. Mack of The Life Sciences Report (3/6/14)

    George Zavoico Prospecting for hidden biotech gems makes sense, says H.C. Wainwright & Co. Managing Director George Zavoico, who recently joined the firm's healthcare equity research team. The digging can be hard, but the rewards of successful diligence are huge. In this interview with The Life Sciences Report, Zavoico takes readers on a discovery tour that follows clinical trial data to new ideas that could bring windfalls to portfolios down the road.

    The Life Sciences Report: What theme do you see working for investors in 2014?

    TLSR: Could you talk about Prana Biotechnology Ltd. (PBT:ASX), which you've just initiated on?

    GZ: Certainly. Prana has a compound called PBT2 in clinical trials. On Feb. 18, the company announced results of its phase 2a trial in Huntington's disease (HD). The primary endpoint in this randomized, double-blind study was the safety and tolerability of PBT2 in patients with HD. The exact primary endpoint was the frequency of adverse events over 26 weeks, and it turned out that the compound met that endpoint. This was not surprising, because the drug had been safely administered to Alzheimer's disease (AD) patients in a previous phase 2a trial.
    Here's where things get interesting. I cautioned investors not to overinterpret and expect statistically significant data on efficacy from phase 2 trials at the start of this interview. This trial, called Reach2HD, was first and foremost a phase 2a safety trial, since PBT2 had never before been given to HD patients. A panel of secondary endpoints—a long list actually—were examined with no expectation of finding statistically significant efficacy results. Recall what I said earlier about looking for trends, not statistical significance. Prana was looking for trends in cognitive function that could then be fashioned into a confirmatory phase 2b trial that would increase the likelihood of showing a clinically significant benefit—a meaningful improvement in cognitive function.
    A surprising thing was discovered in this phase 2a trial. One of the cognitive measures, specifically the Trail Making Test Part B, demonstrated a statistically significant improvement in performance versus placebo at both 12 and 26 weeks. This test is an assessment of executive function—a patient's capacity to plan and organize things and to multitask, which is weakened early on in both HD and AD. The same cognitive function showed a statistically significant improvement with PBT2 in an earlier, phase 2a AD trial, and it is also a secondary endpoint in an ongoing AD trial that's going to read out before the end of March, according to the company's guidance. If this same secondary endpoint is met in the phase 2b trial, that would be confidence building, to say the least.

    TLSR: The results of the high dose of 250 mg versus the low dose of 100 mg are delineated in the phase 2a PBT2 trail. Is the efficacy of the high-dose arm strong compared to the low-dose arm?

    GZ: That's right. Also, in that regard, a very small substudy was performed, in which the brains of four patients in both PBT2 trial arms were imaged. Just as in Alzheimer's disease, the brain shrinks in Huntington's disease. There was some evidence that brain atrophy was reduced in the HD patients taking PBT2. Understand that this was a trend toward conservation of brain volume with PBT2, and was not statistically significant because of the small patient population. But it was an exciting result, nevertheless.

    TLSR: What is it about PBT2 that makes it potentially efficacious in Alzheimer's and Huntington's diseases?

    GZ: The common pathogenesis of these diseases is protein misfolding. The misfolding is facilitated and enhanced by metals—zinc and copper, in particular. The physiologic mechanisms that remove zinc and copper, which are released and exist very transiently in the synapse during neurotransmission, just don't work as well as we age. In younger people, the metals are immediately bound and transported back to their intracellular storage sites. If they stay longer in the synapse—that space between nerve cells—they can interact with those proteins and aggregate. As disease progresses, these metal-binding proteins, or metalloproteins, form plaques, which cause dysfunction in neurotransmission and ultimately an inflammatory response that kills the affected and surrounding neurons. That's when patients begin to get overt symptoms.
    In Alzheimer's and Huntington's diseases, the misfolded proteins are beta-amyloid and mutant huntingtin protein, respectively. PBT2 has a chaperone-type activity that appears to strip zinc and copper from these metalloproteins, then transports them across the neuronal cell membrane and delivers them to intracellular proteins, where the metals are normally stored. In animal models, PBT2 has been shown to reduce the amyloid burden in the brain, meaning that the amount of amyloid plaques is reduced. This is the primary endpoint in the ongoing Alzheimer's disease trial, called IMAGINE, that is expected to read out before the end of March.
    Here's where it may get very exciting. If PBT2 reduces the amyloid burden in Alzheimer's disease patients after a year of treatment, and improves cognitive function, then it will be the only drug candidate to have shown this. In our view, the risk-reward ratio for PBT2 is tremendous.

    Let me just caution readers that PBT2 may also fail to show a reduction in amyloid burden, in which case we expect Prana's stock to take a big hit. But having reviewed the preclinical and early clinical results to date, we think this trial has a better chance of succeeding than failing.…
    schrieb am 26.02.14 16:33:20
    Beitrag Nr. 497 (46.528.369)
    Antwort auf Beitrag Nr.: 46.489.191 von me_2 am 19.02.14 18:51:06Prana Biotechnology Limited Message Board

    djnato2007 • 10 minutes ago

    Adam F has bacically cost me $15000 in 1 month
    He and the Stinking Alpha guys basically made me fail, along with my lack of understanding of the Short bash trickery and being a fearful idiot. Good luck to all you rich guys that can handle the swings. Just another failure for me. Thanks Adam F and the stinking alpha scam.
    schrieb am 25.02.14 13:06:29
    Beitrag Nr. 496 (46.518.993)
    Do NOT buy or sell PRAN until you have read everything. ;)

    What’s the Best Small Cap Huntington's Disease Stock? RPTP, PRAN & OMER…

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