Sangui - Perle im Biotechsektor bald 1ooo % ? - Älteste Beiträge zuerst (Seite 7328)

[Eberhard01]

Antwort auf Beitrag Nr.: 49.876.570 von gradow am 29.05.15 17:38:17

Vernünftige Beiträge, die nicht nur das wiedergeben was Hubi und Jochen vorplappern, sind immer entsprechend ernsthaft beantwortet/kommentiert worden.

[Jaci]

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Dieser Beitrag wurde von MadMod moderiert. Grund: Quelle?

[RTLOLDY]

[EP165] A TOPICAL HAEMOGLOBIN SPRAY FOR OXYGENATING CHRONIC VENOUS LEG ULCERS: A PILOT STUDY

Ray Norris1, Brentwood, United Kingdom , Joy Tickle2, Brentwood, United Kingdom
1South West Essex Community Services North East London NHS Foundation Trust; Tissue Viability
2South West Essex Community Services North East London NHS Foundation Trust

Thursday, May 14, 2015 E-poster session: Devices & Intervention

Aim: This pilot study aims to investigate the effect a topical haemoglobin spray in reducing the size of chronic venous leg ulcers (VLUs).
Method: Patients whose VLU wounds were non-healing after 4 weeks of standard care (decreased wound size <40%) were treated with the haemoglobin spray at each dressing change in addition to standard care for 4 weeks. The spray Is designed to deliver oxygen to wounds through facilitated diffusion. Standard care comprised compression therapy and wound dressings. Wound size, number of dressing changes, wound-bed characteristics, exudate level and patient-reported pain were recorded during the treatment period.
Results / Discussion: Seventeen patients were recruited. Three were withdrawn and data from 14 patients were analysed. Seventeen wounds were assessed; the average baseline wound duration was 41 months (range 6–120). The average wound area decreased from 52.5 cm2 (range 11.25–130.5) before treatment to 45.29 cm2 after treatment, with an average reduction of 7.21 cm2 (range 15.5–96%; median 68%). All participants showed a reduced wound area after the 4-week treatment period, with a reduction of slough and increase in granulation and epithelial tissue, and most reported reduced pain.
Conclusion: Fourteen of the 17 patients were progressing towards healing, despite the relatively short treatment period of 4 weeks. The results support those of two earlier randomised studies on the efficacy of haemoglobin spray on chronic wounds.
NB: The haemoglobin spray used in this study was Granulox (Infirst).

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_…
Seite 18

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[EP251] COMPLETE HEALING WITH HAEMOGLOBIN SPRAY IN 5/6 NON-HEALING DIABETIC FOOT ULCERS THAT FAILED STANDARD CARE

Mike Green1, Birmingham, United Kingdom
1Soho Road Health Centre

Thursday, May 14, 2015 E-poster session: Diabetic Foot

Aim: Foot ulcers are slow to heal and are frequently further delayed by diabetes. The aim of the study was to evaluate the usefulness of haemoglobin spray in the treatment of non-healing foot ulcers.
Method: Patients with non-healing ulcers which had failed to improve despite standard care, had their wounds sharp debrided and cleansed. After cleansing with saline, a thin layer of haemoglobin spray was applied onto the wound area. Hydro polymer foams were used as secondary wound dressing.
Results / Discussion: The wounds of 4 patients (6 wounds in total) used the spray during a 6 month period. 4 wounds healed and 1 showed significant improvement. 3 of the patients had peripheral vascular disease where the vascular surgeon was deemed them not suitable for surgery.
Patient 1 - 2nd toe right foot 4mm x 5mm on 13.3.14 – 13.10.14 wound healed (60 applications)
Patient 2 – 1st metatarsal phalangeal joint right foot 2mm x 2mm on 3.4.14 – 15.5.14 wound healed (12 applications)
Patient 3 – medial side right 1st toe 14mm x 9mm on 24.3.14 – 28.7.14 wound healed (34 applications)
Apex of 1st right toe 6mm x 9mm on 24.3.14 – 26.6.14 wound healed (27 applications)
Patient 4 – Posterior right heel 24mm x 78mm on 16.6.14 – 11.8.14 wound healed (16 applications)
Posterior left heel 22mm x 77mm on 16.6.14 – not resolved, treatment ongoing.
Conclusion: Haemoglobin spray might be an adjunctive therapy option for hard to heal ulcers to accelerate wound healing. Secondarily all patients reported a reduction in wound pain levels.

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_… Seite 1

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[EP020] TREATMENT OF CHRONICAL LOWER LEG ULCERS WITH TOPICAL HEMOGLOBIN SPRAY

Danijela Semenic1, Ljubljana, Slovenia , Adrijana Debelak1, Ljubljana, Slovenia , Irena Jovisic1, Ljubljana, Slovenia , Janja Nikolic1, Ljubljana, Slovenia , Dragica Maja Smrke1, Ljubljana, Slovenia
1University Medical Center Ljubljana; Department of Surgical Infections

Wednesday, May 13, 2015 E-poster session: Leg Ulcer

Aim: Primary diseases such as peripheral arterial occlusive disease, chronic venous insufficiency, diabetic foot syndrome may lead to a long term reduction in oxygen supply to the tissue. Partial pressure of oxygen in tissue is reduced, owing to capillary degeneration, which leads to consequent necrosis and chronic wounds formation.
The healing of chronic wound is accompanied by increased energy metabolism of the skin. It requires more oxygen than normal metabolism of healthy skin. Even if sufficient amount of oxygen is available in the air, it cannot cross the bottom of the wound due to the diffusion barrier. We tested if oxygen from the air can be available for cellular activity and healing through topical application of hemoglobin spray on the wound bed.
Method: In a pilot study we treated 10 patients with chronic lower leg ulcers of different etiology, without systemic or local signs of inflammation. After flushing the wounds with local antiseptic solution, topical hemoglobin spray was used and covered with non-occlusive silicon-polyurethane modern dressing. We applied hemoglobin spray every 2-3 days for 16 weeks.
Results / Discussion: Surface area of ulcers as well as secretion rate have diminished and epithelisation of wound edges and scar formation was noted.
Conclusion: Cells need at least 20mmHg of oxygen partial pressure to survive, wound closure/granulation/epithelisation require a minimum of 40mm Hg. Consequently in the case of hypoxia, stagnation of the wound healing is present. Use of natural oxygen transporter – hemoglobin as a topical application in a form of a spray can be helpful for wound healing.

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_…
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[OP169] PHOTOACUSTIC TOMOGRAPHY FOR NON-INVASIVE DIAGNOSTIC IN PATIENTS WITH CHRONIC VENOUS LEG ULCERS TREATED WITH HEMOGLOBIN SPRAY - FIRST RESULTS OF A PROSPECTIVE CLINICAL STUDY

Ingo Stoffels1, Essen, Germany , Petri Maximilian1, Essen, Germany , Julia Leyh1, Essen, Germany , Joachim Dissemond1, Essen, Germany , Joachim Klode1, Essen, Germany
1University Hospital Essen; Department of Dermatology

Friday, May 15, 2015 Free Paper Session: Leg Ulcer 2

Aim: Improvement of oxygenation is getting increasing attention in modern wound care. Therefore the intention of this prospective clinical study (DRKS-ID: DRKS00005993) was to measure the potential increase of oxygenated hemoglobin in chronic venous leg ulcers after topical application of haemoglobin spray with photoacustic tomography (PAT).
Method: Laser-light with different wavelengths is applied on the wound surfaces. The laser-light encounters hemoglobin, which can be oxygenated or desoxygenated. Hemoglobin is a chromophore, which is a strong absorber for laser-light. The absorbance depends on the status of oxygenisation. The environment is heating through the absorbtion of laser-light and is enlarging. Therefore a short laser impulse creates an ultrasound echo, which can be detected via an ultrasound detector. The resulting sound wave patern is converted to a high resolution image. Thus, the concentration of oxygenated and desoxygenated hemoglobin in wounds is reliable imaged and quantifiable. We measured chronic venous leg ulcers via PAT before, 5 min., and 20 min. after application of hemoglobin spray.
Results: Between July and November 2014 altogether 20 patients with chronic venous leg ulcers were included. The median percentage of oxygenated hemoglobin in the wounds before application of hemoglobin spray was significantly lower compared to 20 min. after topical hemoglobin application (58.5% vs 75.5%, p=0.047).

Conclusion: PAT is a new and innovative option to measure differences in the amount of oxygentaed hemoglobin in chronic wounds. Importantly, topical application of hemoglogin spray increases significantly the amount of oxygenated hemoglobin in chronic venous leg ulcers.

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_…
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[OP170] IMPROVING OUTCOMES IN CHRONIC VENOUS LEG ULCERS WITH A TOPICAL HAEMOGLOBIN SPRAY, USING POST HOC ANALYSIS AND SIMULATION OF WOUND CLOSURE

Petr Arenberger1, Prague, Czech Republic , Fredrik Elg2, London, United Kingdom , Keith Cutting3, Richmansworth, United Kingdom
1Charles University in Prague; Department of Dermatology
2Infirst Healthcare
3Bucks New University

Friday, May 15, 2015 Free Paper Session: Leg Ulcer 2

Aim: To evaluate the effect of topical haemoglobin spray on treatment response and wound-closure rates in patients with chronic venous leg ulcers. Method: A linear regression model was used to forecast healing outcomes over a twelve-month period. Simulated data was taken from normal distributions based on post-hoc analysis of a 72 patient study (36 standard care, 36 patients standard care plus topical haemoglobin spray). Using a simulated 25,000 “patients” from each arm the proportion of wound closure over time was projected.
Results: Simulation results predicted a 55% wound closure rate at 6 months in the haemoglobin arm, compared to 4% in the standard care arm. Over a 12-month simulation period a 43% overall reduction in wound burden was predicted. 85% of wounds were expected to heal in the haemoglobin spray arm by 12 months compared to 13% in the standard care arm.
Conclusion: Topical haemoglobin spray promises a considerably more effective treatment for chronic venous leg ulcers than standard care alone. Further research is required to validate these predictions and to identify achievable outcomes in other chronic wound types.

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_…
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[EP177] TREATMENT OF INFECTED CHRONIC LEG ULCERS COMBINING INFECTION CONTROL, SURGICAL MODALITIES, HEMOGLOBIN SPRAY, WOUND DRESSING, AND COMPRESSION THERAPY

Peter Engels1, Georgsmarienhütte, Germany , Nesat Mustafi2, Frankfurt, Germany
1Sastomed GmbH
2Krankenhaus Nordwest GmbH

Thursday, May 14, 2015 E-poster session: Devices & Intervention

Title: Treatment of burns with haemoglobin spray as adjunctive therapy to standard care.

Authors: Nesat Mustafi & Peter Engels

Aim: Burns affect the integrity of the skin and can ultimately result in skin scarring. Current therapeutic goals of wound treatment focus on the reduction of scar formation and severity. However, scar formation itself varies from patient to patient and within an individual based on the location of the wound. Therefore, the preparation of customized treatments for individual patients represents an important therapeutic goal in the fields of burns and wound healing. The objective of this study has been to evaluate the usefulness of haemoglobin spray in the treatment of burns and its impact on scar formation.
Method: Burn wounds were mechanically debrided or cleansed. After rinsing with an antimicrobial solution, a thin layer of haemoglobin spray was applied onto the wound area. Hydro polymer foams served as secondary wound dressing.
Results / Discussion: Burn wounds from ten different patients are shown and treatment results are highlighted. The wound severities range from grade 1 to grade 2B. In particular, for grade 2 wounds the scar formation was an important aspect of the evaluation. In all cases, we observed a fast healing of the burns. In addition, skin integrity and scar formation seemed to be improved.
Conclusion: Haemoglobin spray might be an adjunctive therapy option for severe burns (2A & B) to accelerate wound healing and improve skin integrity.

http://www.ewma2015.org/fileadmin/user_upload/EWMA/pdf/EWMA_…
Seite 30

[Jaci]

Antwort auf Beitrag Nr.: 49.880.167 von RTLOLDY am 30.05.15 12:23:31

Soviel zum Thema: "ich kopiere mal irgendwo was raus und poste es ohne eigenen Content oder Sinn und Verstand".

Aber was lese ich da: der gute Nesat Mustafi, der bereits für dies oder jenes Produkt Reklame betrieb, ist auch wieder dabei. Na, dann werden sich die Umsatzzahlen ja bestimmt signifikant verbessern....



Man stelle sich vor, Sangui erlöst im nächsten Quartal sagenhafte 18 TUSD. Ich vermag mir dann die Jubelarie gar nicht vorzustellen:

"Sangui auf dem Weg in eine neue Dimension; Umsatzsteigerung von über 50% erzielt!!"

[gradow]

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Dieser Beitrag wurde von MadMod moderiert. Grund: themenfremder Inhalt

[guxx]

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Dieser Beitrag wurde von MadMod moderiert. Grund: Korrespondierendes Posting wurde entfernt

[invest-2011]

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Dieser Beitrag wurde von MadMod moderiert. Grund: themenfremder Inhalt

[invest-2011]

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Dieser Beitrag wurde von MadMod moderiert. Grund: Provokation

[invest-2011]

!

Dieser Beitrag wurde von MadMod moderiert. Grund: Provokation

[guxx]

!

Dieser Beitrag wurde von MadMod moderiert. Grund: Provokation