BriaCell Announces Clinical Data as Presented at the 2019 San Antonio Breast Cancer Symposium - Seite 2

Session Date:  Friday, December 13, 2019 at 6:00 p.m. ET
Summarized Data:

• In this poster, cancer associated macrophage-like cells (CAML), specialized myeloid cells found in peripheral blood and associated with the presence of solid tumors, was measured to determine their prevalence, specificity, and sensitivity in advanced breast cancer patients who were treated with Bria-IMT regimen.
• Patients with decreases in CAML size during treatment with the Bria-IMT regimen, alone or in combination with KEYTRUDA, or other therapies, appear to be more likely to respond to treatment with tumor reduction and have a longer disease-free survival.

Copies of the posters will be posted at the following: https://briacell.com/novel-technology/scientific-publications/.

"We are intrigued by the initial data for Bria-IMT in combination with checkpoint inhibitors in advanced breast cancer patients suggesting additive or synergistic effects," said Dr. Bill Williams, President & CEO of BriaCell. "The identification of a novel subset of patients with a very high response rate, if confirmed with further clinical evaluation, will allow us to focus our development plans on the patients most likely to benefit. We plan to provide additional data as we continue to treat breast cancer patients with novel combinations of Bria-IMT with checkpoint inhibitors."

About BriaCell

BriaCell is an immuno-oncology focused biotechnology company developing targeted and safe approaches for the management of cancer.

BriaCell is conducting a Phase I/IIa clinical trial of Bria-IMT, BriaCell’s lead candidate, in a Combination Study with immune checkpoint inhibitors such as the Incyte drugs INCMGA00012 (an anti-PD-1 antibody similar to pembrolizumab [KEYTRUDA; manufactured by Merck & Co., Inc. (NYSE: MRK)]) and epacadostat, an orally bioavailable small-molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1). The combination study is listed in ClinicalTrials.gov as NCT03328026.

BriaCell currently has a non-exclusive clinical trial collaboration with Incyte Corporation to evaluate the effects of combinations of novel clinical candidates. Under the agreement, Incyte and BriaCell will be evaluating novel combinations of compounds from Incyte’s development portfolio with BriaCell’s drug candidates in advanced breast cancer patients.

BriaCell is also developing Bria-OTS, an off-the-shelf personalized immunotherapy, for advanced breast cancer. Bria-OTS immunotherapy treatments are personalized to match the patient without the need for personalized manufacturing. Bria-OTS, which is expected to cover over 99 percent of the patient population, is designed to produce a potent and selective immune response against the cancer of each patient while eliminating the time, expense and complex manufacturing logistics associated with other personalized immunotherapies.