New Paper Documents Effectiveness Of Natural Physiological Salts As New Hygienic Intervention To Reduce The Exhalation Of Particles That Transmit Airborne Infectious Disease - Seite 2

The researchers set out to determine whether nasal delivery of the calcium and sodium salts in a formulation called FEND (Fast Emergency Nasal Defense) by Sensory Cloud's Nimbus, could substantially suppress exhalation of bioaerosols without targeting the entire lungs.  The authors found a strong correlation between high numbers of exhaled particles and age, with the group older than 65 exhaling on average 6,641 particles per liter of air, while the group younger than 65 exhaled on average 440 particles per liter.  Delivery of FEND by nasal inspiration of the Nimbus cloud reduced exhalation of bioaerosol by 99% for the entire group, for up to 6 hours. Most of the suppressed airborne particles were smaller in size than those effectively filtered by conventional face masks.

Summarizing research conducted over the last 15 years at Pulmatrix, with animal and human studies performed at labs in the UK, US and Canada, the authors document how an aerosol comprised of unique combinations of calcium and sodium salts improves the barrier function of the mucus lining to protect against infection and promotes natural innate immune disinfectant properties suited to defense against a range of bacterial and viral infections, including Influenza A, Influenza B and parainfluenza strains.

The paper also documented, in the case of an influenza swine model, the complete blockage of airborne transmission of the disease through the administration of the saline compound.

For immediate human use as a new purely hygienic intervention, the authors proposed the Nimbus, a hand-held nasal mister developed by Edwards' company Sensory Cloud, given its ability to generate FEND aerosols of approximately 10 microns in diameter, ideally suited for distribution of the FEND composition to the upper airways where bioaerosol is largely generated.

"With today's healthcare crisis we believe a nasal cleanser to be the best and fastest approach as a defensive measure against the rapid spread of COVID-19," the authors wrote in QRB Discovery. "Beyond diminishing viral bioaerosol expulsion into the environment, these particular combinations of calcium and sodium salts delivered to the nose are likely to decrease the same bioaerosols from reaching the lungs via inhaled air, the only route for virus to reach this organ."