Bioxytran Gets Broad Patent Coverage on 60+ Viruses

Claims cover method of treating a viral infection with a lectin-binding carbohydrate

BOSTON, MASSACHUSETTS, Oct. 24, 2023 (GLOBE NEWSWIRE) -- BIOXYTRAN, INC. (BIXT), (the “Company”), a clinical stage biotechnology company developing oral and intravenous drugs to treat COVID-19 and other viral diseases, announced that the U.S Patent and Trademark Office (USPTO) has published the Company’s patent application WO2023178228A1 Lectin-binding carbohydrates for treating viral infections. The pending patent covers broad claims about the use of hundreds of combinations of antiviral complex carbohydrate drugs to treat over 60 named viruses.

Google Patent link:
https://patents.google.com/patent/WO2023178228A1/en

The glycovirology platform is a market forming technology with potentially wide-reaching implications. This patent represents what we believe is a new direction in the evolution of antiviral therapies that originally started during the HIV epidemic. The first antiviral agents were nucleoside/nucleotide reverse transcriptase inhibitors (NRTI’s) which would make their way to the infected cells and prevent the cell from reading the viral code and converting it into copying DNA. As drug resistance emerged, protease inhibitors which cleave the polypeptides into usable viral proteins were blocked to disrupt the viral replication process. Eventually a combination of therapies known as Highly Active Antiretroviral therapy (HAART) became the standard of care for the past 25 years. The current Mechanism of Action (MOA) of almost all antivirals traces its roots to the disruption of the viral replication cycle. Bioxytran, with its complex carbohydrate entry inhibitor, is a next generation antiviral which prevents cellular entry by neutralizing the virus outside of the cell so it never gets in the cells to replicate.

Bioxytran has completed 3 successful in-vitro tests for COVID-19, RSV, and H1N1 that demonstrate the potential of our galectin antagonist to be used as a broad-spectrum antiviral. Further research is needed to determine the boundaries of the broad-spectrum activity. Many of the indications claimed in the patent are based on scientific research that made the case that galectins are involved in the cellular entry mechanism and that blocking them interferes with their ability to enter the cell, or that galectins are involved in the overall disease pathology. When forming our initial hypothesis in March 2020 that a galectin antagonist could interfere with the SARS-CoV-2 spike protein, the existing research at the time led us to see the similarities between the HIV spike protein and the SARS-CoV-2 spike protein. Since our initial thesis was published in March 2020 over 40 scientific journal articles have been published on the topic.