Chi-Med to Discuss Select Global Clinical Trial Data Presented at ASCO20

― Savolitinib in MET exon 14 skipping NSCLC efficacy evaluable patients demonstrated 49.2% ORR, 93.4% DCR and 9.6 months DoR, including 36% patients with more aggressive disease subtype ―

― Savolitinib vs. sunitinib study in PRCC patients demonstrated 27% vs. 7% ORR, with no savolitinib responding patients with disease progression at data cut-off, and encouraging overall survival hazard ratio of 0.51 with median not reached ―

― Ongoing surufatinib study in U.S. progressive NET patients demonstrated promising efficacy irrespective of prior lines of therapy ―

― Audio call and webcast on Monday, June 1 at 8 a.m. EDT to review select presentations ―

LONDON, May 29, 2020 (GLOBE NEWSWIRE) -- Hutchison China MediTech Limited (“Chi-Med”) (Nasdaq/AIM: HCM) today showcases new and updated analyses on the ongoing studies of savolitinib and surufatinib at the ASCO20 Virtual Scientific Program, May 29-31, 2020.  Chi-Med will hold a conference call and audio webcast on Monday, June 1, 2020, at 1 p.m. GMT / 8 a.m. EDT / 8 p.m. HKT to review select clinical data and discuss development plan next steps.

A live audio webcast of the call will be broadcast via Chi-Med’s website at www.chi-med.com/event. Investors may participate in the call using one of the following dial-in numbers: 1‑866‑213‑0992 (U.S. toll-free) / 0800‑032‑2849 (U.K. toll-free) / [phone] (Hong Kong).  Additional dial-in numbers are also available at Chi-Med’s website.  Please use participant access code “6929001#.”

Savolitinib, a potent, highly selective oral inhibitor of mesenchymal epithelial transition receptor (“MET”)

In clinical studies to date, involving over 1,000 patients, savolitinib has shown promising clinical efficacy in patients with MET gene alterations in multiple tumor types with an acceptable safety profile.

Presentation Title:	Phase II study of savolitinib in patients with pulmonary sarcomatoid carcinoma (“PSC”) and other types of non-small cell lung cancer (“NSCLC”) harboring MET exon 14 skipping
Authors:	S Lu, J Fang, X Li, L Cao, J Zhou, Q Guo, Z Liang, Y Cheng, L Jiang, N Yang, Z Han, J Shi, Y Chen, H Xu, H Zhang, D Zhang, J Li, L Wang, Y Ren, W Su
Abstract Link:	9519

This is an ongoing China Phase II study of savolitinib monotherapy in NSCLC patients with MET exon 14 skipping mutations who have failed prior systemic therapy or are unable to receive chemotherapy (clinicaltrials.gov number NCT02897479), in which savolitinib demonstrated promising anti-tumor activity and acceptable tolerability.  Approximately 35% of patients in the study have an aggressive subtype of NSCLC, PSC.¹  Treatment naïve patients accounted for approximately 40% of the treated patients while the remainder received prior treatments.