Zealand Pharma presents clinical and non-clinical evidence for dasiglucagon rescue therapy at the 80th Scientific Sessions of the American Diabetes Association - Seite 2

Dr. Timothy Bailey, President and CEO of AMCR Institute, presented a poster entitled Dasiglucagon HypoPal Autoinjector as a Fast and Effective Treatment for Severe Hypoglycemia:  Results of a Phase 3 Trial (Abstract Number: 1053-P). This Phase 3 parallel, two-arm study in 45 adults with Type 1 diabetes, investigated the recovery from insulin-induced hypoglycemia with dasiglucagon versus placebo. All primary and secondary endpoints were met and the median time to plasma glucose recovery was 10 minutes with dasiglucagon versus placebo 35 minutes, (p<0.0001). Dasiglucagon was generally safe and well-tolerated and these results were consistent with prior pivotal Phase 3 trials evaluating dasiglucagon administered via a pre-filled syringe.

Dr. Carola Wenander, Principal Scientist, In Vivo Pharmacology at Zealand Pharma, presented a poster entitled PK/PD of Glucagon and the Novel Glucagon Analog, Dasiglucagon, in Aqueous or Non-Aqueous formulations following SC Administrations in Rats (Abstract Number: 1091-P). This PK/PD study in male Sprague-Dawley rats characterized the pharmacokinetics of glucagon in aqueous formulation (phosphate buffered solution) and that formulated in DMSO, and compared these to the pharmacodynamics of dasiglucagon in an aqueous formulation. The pharmacodynamic results of this preclinical model demonstrated that there was comparable blood glucose increase with glucagon and dasiglucagon in aqueous formulations. Glucagon in DMSO showed a delayed increase in blood glucose.

Adam Steensberg, Executive Vice President of Research and Development, and Chief Medical Officer at Zealand Pharma stated, “Zealand Pharma is focused on bringing life changing therapies to people with diabetes and believe that the data presented at ADA further demonstrate the potential of dasiglucagon as a fast and effective treatment for severe hypoglycemia in both adults and pediatrics.”

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Dasiglucagon (glucagon analog stable in liquid formulation) for use in multiple indications
Dasiglucagon is a Zealand Pharma-invented glucagon analog with a unique stability profile in a ready-to-use aqueous solution. It is also in development for four indications: treatment of severe hypoglycemia, treatment of type 1 diabetes with a next-generation artificial pancreas, treatment for children born with a genetic mutation that causes congenital hyperinsulinism (CHI), and mini doses to treat post prandial hypoglycemia.