Sutro Biopharma Announces Presentation of Data for Luveltamab Tazevibulin (luvelta) from the Phase 1 Dose-Expansion Study in Endometrial Cancers at ESMO 2023

- Luvelta demonstrated encouraging preliminary anti-tumor activity (29% response rate) in late-stage patients with recurrent/relapsed endometrial cancer with tumor proportion score (TPS) >25% FolRα expression –

- Safety profile was consistent with prior data in patients with platinum-resistant ovarian cancer -

SOUTH SAN FRANCISCO, Calif., Oct. 22, 2023 (GLOBE NEWSWIRE) -- Sutro Biopharma, Inc. (Sutro or the Company) (NASDAQ: STRO), a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs), today announced initial results from a Phase 1 dose-expansion study of luveltamab tazevibulin (luvelta), a novel Folate receptor alpha (FolRα)-targeting ADC, in patients with endometrial cancer, in a mini oral presentation at the 2023 European Society For Medical Oncology (ESMO) Congress in Madrid, Spain.

Initial data from the Phase 1 dose-expansion study of luvelta were presented by Bhavana Pothurri, M.D., Professor, Department of Obstetrics and Gynecology at NYU Grossman School of Medicine and Director, Gynecologic Oncology Research at NYU Langone, Perlmutter Cancer Center.

Advanced endometrial cancer is the only gynecologic malignancy with increasing incidence and mortality in both the US and Europe¹. Estimated incidence in the EU: 92,746 pts with 23,047 deaths (2022)² and in the US: 66,000 pts with 13,030 deaths (2023)³.

“We are pleased to have the opportunity to present these encouraging early data at ESMO this year,” said Anne Borgman, M.D., Sutro’s Chief Medical Officer. “The late-stage endometrial cancer treatment landscape is still evolving. With checkpoint inhibitors moving to first line, single agent chemotherapy with response rates in the 15% range⁴ may once again be the default therapy for patients whose tumors recur. We are optimistic that luvelta may be able to address this tremendous unmet need with a new targeted treatment option, given endometrial cancer expresses FolRα, along with the manageable tolerability profile and preliminary anti-tumor activity seen in the trial.”

FolRα is a validated anti-tumor target in ovarian cancer that is overexpressed in endometrial cancer compared with normal tissue⁵. As presented in June 2023 at the American Society of Clinical Oncology, luvelta has already demonstrated compelling preliminary efficacy and safety in patients with a broad range of FolRα-expressing recurrent epithelial ovarian cancers (EOC) in a Phase 1 dose escalation/expansion study.