Largest Ever Real-World Evidence Study of Ambulatory Cardiac Monitoring Demonstrates Clinical Superiority of iRhythm's Zio Long-Term Continuous Monitoring Service

• Findings published in the American Heart Journal show higher clinical diagnostic yield and lower odds of retesting with Zio long-term continuous monitoring service (LTCM) compared to other LTCM and ambulatory cardiac monitoring (ACM) products
• LTCM was associated with lower incremental health care utilization and cost

SAN FRANCISCO, Jan. 05, 2024 (GLOBE NEWSWIRE) -- (NASDAQ:IRTC) today announced that the results from the Cardiac Ambulatory Monitor EvaLuation of Outcomes and Time to Events (CAMELOT) study have been published in the American Heart Journal (AHJ).

The peer-reviewed manuscript, titled “Comparative Effectiveness and Healthcare Utilization for Ambulatory Cardiac Monitoring (ACM) Strategies in Medicare Beneficiaries,” reveals that the Zio long-term continuous monitoring service (LTCM), which features up to 14 continuous days of monitoring, was independently associated with the highest yield of clinical arrhythmia encounter diagnosis and lowest likelihood of retest. The retrospective study of almost 300,000 patients makes CAMELOT the largest published real-world comparative effectiveness analysis of ambulatory cardiac monitoring.

“Our findings reveal significant variation in selection of monitoring devices, which can be influenced by patient characteristics and other factors. However, long-term continuous monitoring — and iRhythm’s Zio LTCM in particular — was independently associated with a higher probability of an arrhythmia diagnosis being documented and a lower probability of repeat testing," said Matthew Reynolds, MD, MSc, a cardiac electrophysiologist at Lahey Hospital & Medical Center and the study's lead author. “LTCM also minimized subsequent health care spending, compared to traditional Holter monitors or non-continuous event monitors. We believe these findings may be useful for clinicians in choosing the best type of monitor for different clinical scenarios.”

Higher Diagnostic Yield and Lower Likelihood of Retest

The investigators sought to determine the impact of choice of monitoring service and strategy on a range of clinical and health economic outcomes. Using the full (100%) sample of Medicare beneficiaries, the investigators identified 287,789 patients who had previously not received cardiac monitoring or arrhythmia diagnosis in the 12 months prior to the index date (baseline period).