Genetic Immunity Grants Exclusive License of Therapeutic HIV Vaccine Technology to JSC Pharmadis for Russia and Commonwealth of Independent States - Seite 2

"We will do our best to support the clinical trial planned for 2019 in Moscow, and expect to see a positive outcome," added Kovalev.

Plasmid DNA-based vaccines have been proven safe, but poorly immunogenic in human subjects. Genetic Immunity has developed several technologies to improve the immunogenicity of DNA-encoded antigens, including:

• Antigeneering of plasmid DNA to safely and authentically express most of the antigens of HIV or other pathogens, including cancer.
• The formulation of plasmid DNA to a pathogen-like nanoparticle called NanoComp. These nanoparticles target professional antigen-presenting cells, such as Langerhans cells and dendritic cells.
• A targeted transdermal delivery device called DermaPrep. It has been shown that topical DermaPrep administration results in antigen expression in the lymph nodes by dendritic cells.

"Following successful preclinical studies, we completed a Phase I, Phase I/II, conducted by the AIDS Clinical Trials Group and funded by the National Institutes of Health in the USA, and a Phase II trial."

"In these studies, we have successfully demonstrated that DermaVir immunization induces new, HIV-specific memory T-cells that correlated to the amount of nanomedicine the subject received. Our data to date supports proof of concept, the relationship between DermaVir-induced antiviral immune responses and clinical benefit," concluded Rozsnyay.

About Genetic Immunity  

Genetic Immunity is a development stage biotechnology company focusing on therapeutic vaccine research. The company's proprietary platform technology is based on trans-dermally delivered pDNA that can be effective in boosting the immune system to fight diseases, including viral infection like HIV, various cancers, allergies, and more. Genetic Immunity's lead product candidate for the treatment of HIV has completed three clinical trials to date with well-established immune-boosting properties. Building on the HIV data to date, the Company is now expanding its product portfolio to several cancer indications. http://www.geneticimmunity.com

About Pharmadis 

Pharmadis is one of the largest medical distribution companies in Russia with four primary divisions: Pharmaceuticals, Consumable Medical Goods, Medical Equipment, and Technical Support and Engineering. The company has authorizations from numerous international medical companies, including Johnson & Johnson, Baxter, Siemens, Philips, GE, Bayer, among many others. Pharmadis is consistently expanding its activity to implement innovative solutions in medicine in Russia. http://www.pharmadys.ru    

Further information: Viktor Rozsnyay, CEO, Genetic Immunity, [e-mail]

Media enquiries: Vladislav Shayman, Managing Partner, Expertise Institute, [e-mail]