Positive results from Avillion's Phase 2 trial of sonelokinab (M1095) in chronic psoriasis to be presented today in Late-Breaking News Session at EADV 2020 Virtual - Seite 2

The Late-Breaking Abstract, entitled: "A Phase 2B, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Assessing the Efficacy, Safety, and Tolerability of Sonelokinab (M1095), an IL-17A/F Nanobody, in Patients with Moderate-to-Severe Chronic Plaque Psoriasis: Results from 24 Weeks," will be presented today at 14:45 CET by internationally recognised dermatology expert Kim Papp, MD, PhD, FRCPC, President of Probity Medical Research and principal investigator of the study.

Commenting on the results, Dr Papp said: "The data generated from this study of sonelokinab, the first nanobody tested in psoriasis, are extremely encouraging.  These data suggest sonelokinab may represent an important advance in the search for new and improved treatments for psoriasis. Our data reinforces the advantage of targeting both IL-17A and IL-17F. Psoriasis remains a serious condition affecting all aspects of patients' lives.  The development of new therapies is an ongoing challenge. Should larger studies confirm the speed of effect, durability and tolerability of sonelokinab demonstrated in this study, sonelokinab could become an important addition in our arsenal of therapies intended to improve patients' lives.  Sonelokinab could prove to be an advancement on existing therapies in the dermatologist's psoriasis armamentarium."

Allison Jeynes, MD, Chief Executive Officer of Avillion, added: "These positive results clearly highlight the potential of sonelokinab. The smooth running and rapid completion of the trial ahead of schedule exemplifies how we seek to add value to our in-licensed assets, in this case from Merck KGaA Darmstadt, Germany. We are grateful to the investigators and patients across North American and Europe."

About sonelokinab (M1095)

The Anti-IL-17 A/F Nanobody sonelokinab is an investigational bi-specific half-life-extended Nanobody that is thought to neutralise both IL-17A and IL-17F with the potential to treat inflammatory diseases. Due to the small size and unique structure of Nanobodies, they could be an ideal building block for a new generation of novel biological drugs.

Merck KGaA Darmstadt, Germany acquired full, exclusive rights to anti-IL-17 A/F Nanobody through a global development and commercialisation deal with Ablynx in 2013. Avillion entered into a co-development agreement with Merck KGaA Darmstadt, Germany for the Phase 2 and Phase 3 development of sonelokinab in March 2017.