Wellbeing Subsidiary KGK Science Announces Successful Results of UP360, a Nutraceutical Ingredient Demonstrating Beneficial Immune Defense Response

Wellbeing Digital Sciences Inc. (“Wellbeing” or the “Company”) (NEO: MEDI) (OTC: KONEF) (FRA: SQ2), an evidence-based mental healthcare company focused on the development and implementation of innovative clinical solutions, including psychedelic medicine and digital therapeutics as supported by clinical research, announced today that a clinical study conducted by its wholly owned subsidiary KGK Science Inc. (“KGK”), has shown positive results of UP360 supplementation in helping mount a robust immune response following influenza vaccination.

UP360, a naturally-derived health and wellness ingredient developed by Unigen Inc. (“Unigen”), contains extracts from both the Poria cocos mushroom and rosemary as well as Aloe vera gel powder. The resultant proprietary blend of these botanical ingredients in UP360 produces antioxidant, anti-inflammatory, and immunomodulatory effects. This is the first study to examine a proprietary combination of these ingredients using a human vaccine model. The randomized, triple-blind, placebo-controlled clinical trial involving supplementation with UP360 provides evidence for a robust, healthy immune response in adults following influenza vaccination.

Healthy adult participants between 40-80 years of age, who had not yet received their influenza vaccine, were randomized to either UP360 or placebo for 56 days. Halfway through the study, at day 28, participants received a flu vaccine. The results, published in Frontiers in Nutrition, showed that supplementation with UP360 significantly increased the percentage of TCR gamma-delta cells, known to provide a first line of immune defense for mucosal membranes, in the post-vaccination period compared to placebo. Furthermore, participants supplemented with UP360 had significant increases in blood levels of glutathione peroxidase – antioxidative stress biomarker – and influenza B-specific IgG antibodies before and after vaccination, respectively.

“UP360 supplementation provided a beneficial immune defense response and improved antioxidant function in conjunction with traditional vaccination, adopted by many as part of their overall immune health strategy,” says Dr. Corey Hilmas, Chief Scientific Affairs and Regulatory Officer at KGK Science. “Using a vaccine model offered a unique strategy to evaluate the effect of UP360 oral administration on the immune response.”