Inozyme Pharma Announces Presentation at the American Society of Nephrology (ASN) Kidney Week 2023

BOSTON, Oct. 26, 2023 (GLOBE NEWSWIRE) -- Inozyme Pharma, Inc. (Nasdaq: INZY) (“Inozyme” or the “Company”), a clinical-stage rare disease biopharmaceutical company developing novel therapeutics for the treatment of pathologic mineralization and intimal proliferation, today announced an oral presentation at the American Society of Nephrology (ASN) Kidney Week 2023, which is being held November 2-5, 2023 in Philadelphia, PA.

Details of the presentation are as follows:

Title: Role of Plasma Inorganic Pyrophosphate in Calciphylaxis: A Prospective Study
Format: Oral Abstract Session – Research Advances in Bone and Mineral Metabolism
Date: Thursday, November 2, 2023
Session Time: 5:42-5:51 p.m. ET
Presenting Author: Api Chewcharat, M.D., M.P.H. (Clinical Fellow, Nephrology, Massachusetts General Hospital)
Senior Author: Sagar Nigwekar, MD, MMSc (Co-Director, Kidney Research Center, Massachusetts General Hospital)

Calciphylaxis is a rare disorder with a high mortality rate that mostly affects patients with end stage kidney disease (ESKD). The disease is associated with low levels of pyrophosphate (PPi) and is characterized by pathologic mineralization and intimal proliferation (the overgrowth of smooth muscle cells inside blood vessels) of the vasculature in the skin and fatty tissue leading to blood clots, painful skin ulcers, serious infections, and death. Patients with calciphylaxis have a reported one-year survival rate of approximately 50%. The estimated incidence of calciphylaxis is at least 1,800 new patients per year in the United States and there are no approved therapies.

Inozyme previously presented data at the European Calcified Tissue Society Congress (ECTS) which showed that morbidity and mortality in patients with calciphylaxis were associated with low levels of PPi. The Company has received allowance of its investigational new drug (IND) application from the U.S. Food and Drug Administration (FDA) to evaluate INZ-701 in a clinical trial in patients with ESKD and calciphylaxis.

About INZ-701

INZ-701, a recombinant Fc fusion protein, is an ENPP1 enzyme replacement therapy in development for the treatment of rare disorders of the vasculature, soft tissue, and skeleton. In preclinical studies, the experimental therapy has shown potential to prevent pathologic mineralization and intimal proliferation, which can drive morbidity and mortality in devastating genetic disorders such as ENPP1 Deficiency and ABCC6 Deficiency. INZ-701 is currently in clinical trials for the treatment of ENPP1 Deficiency and ABCC6 Deficiency.