New Data Shows Greater In Vitro Potency for VIBATIV(R) (Telavancin) Against Multidrug-Resistant Gram-Positive Bacteria, Including MRSA, Compared to Alternative Antibiotic Treatments - Seite 2

Data from the presented studies showed that unlike the comparator antibiotics, the in vitro potency of VIBATIV was consistent regardless of the susceptibility profile of the isolates, ranging from those broadly susceptible to antibiotic treatment to MDR strains. Combined, these studies' findings further supplement the extensive and well documented evidence of the in vitro potency of VIBATIV against a broad collection of difficult-to-treat and MDR Gram-positive clinical pathogens, including MRSA. 

"We believe that these latest in vitro study results further support the position that VIBATIV is a key therapeutic option for patients in those instances in which vancomycin or other therapies are not effective or appropriate for treating infections that are susceptible to VIBATIV therapy," stated Jon Bruss, M.D., Vice President Clinical Development & Medical Affairs at Theravance Biopharma. "These represent important findings as we continue to work to educate physicians and healthcare practitioners on the ability of VIBATIV to serve as an essential tool in their antibiotic treatment armament, particularly in an environment in which many pathogens are becoming more challenging to treat."

VIBATIV is a bactericidal, once-daily, injectable lipoglycopeptide antibiotic with in vitro potency and a dual mechanism of action whereby telavancin both inhibits bacterial cell wall synthesis and disrupts bacterial cell membrane function. The drug's proven efficacy against difficult-to-treat infections has been demonstrated in several large, multinational registrational studies, which involved one of the largest cohorts of patients with MRSA infections studied to date. Additionally, there is extensive and well-documented evidence of the drug's in vitro potency and in vivo activity against a broad collection of bacterial pathogens, including those that are considered difficult-to-treat and multidrug-resistant.

About VIBATIV^® (telavancin)

VIBATIV^® was discovered internally in a research program dedicated to finding new antibiotics for serious infections due to Staphylococcus aureus and other Gram-positive bacteria, including MRSA. VIBATIV is a bactericidal, once-daily, injectable lipoglycopeptide antibiotic with in vitro potency and a dual mechanism of action whereby telavancin both inhibits bacterial cell wall synthesis and disrupts bacterial cell membrane function. VIBATIV for injection is approved in the U.S. for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by susceptible isolates of Staphylococcus aureus when alternative treatments are not suitable. In addition, VIBATIV is approved in the U.S. for the treatment of adult patients with complicated skin & skin structure infections (cSSSI) caused by susceptible isolates of Gram-positive bacteria, including Staphylococcus aureus, both methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains.