Cantargia Presented Positive Phase I Clinical Data with Lead Candidate CAN04 at ESMO - Seite 2

"Presenting the first clinical dataset from CAN04 treatment of patients with advanced cancer at a major cancer conference is an important milestone for Cantargia. The results have strengthened our view that CAN04 can become an important future cancer therapy. We look forward to the last step in the Phase I part and the initiation of Phase IIa in NSCLC and pancreatic cancer using an expanded number of clinical sites," said Göran Forsberg, CEO of Cantargia.

The primary objective of the Phase I part of CANFOUR is to assess safety and tolerability of weekly CAN04 in order to define the Maximum Tolerated Dose/Recommended Phase II Dose. Patients with relapsed or refractory non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC), breast or colorectal cancer are eligible in the initial part of the trial using a 3+3 dose escalation design.

The Phase I part of the trial is currently in the final stage and is planned to be finalized during Q4 2018 with phase IIa also starting Q4 2018. Besides monotherapy, combination with cisplatin/gemcitabine in NSCLC or gemcitabine/nab-paclitaxel in pancreatic cancer at an earlier stage of the disease will be studied in phase IIa. More details on the trial design can be found at www.clinicaltrials.gov .

This constitutes information that Cantargia AB is required to publish under the EU's Market Abuse Regulation. The information was submitted for publication through the above contact person on October 20, 2018, at 12:30.

About Cantargia
Cantargia AB (publ), reg.no. 556791-6019, is a biotech company that is developing antibody-based treatments for life-threatening diseases. The original discovery by the research team behind Cantargia was the overexpression of a specific target molecule, interleukin 1 receptor accessory protein (IL1RAP) in leukemic stem cells. Subsequent research has also identified IL1RAP in many other forms of cancer. The company's main project, the CAN04 (nidanilimab) antibody targeted against IL1RAP, is being studied in the CANFOUR clinical phase I/IIa study, where the primary focus is on non-small cell lung cancer and pancreatic cancer. CAN04 (nidanilimab) has two modes of action: it blocks the function of IL1RAP and stimulates the immune system to destroy tumour cells. Cantargia's second project, currently in the research phase, is aimed at developing an IL1RAP-binding antibody that is optimised for treatment of autoimmune and inflammatory diseases.