Oxurion NV – Expert Presentation of Positive Topline Data from a Phase 1 Study evaluating THR-687 for the treatment of DME,at Angiogenesis, Exudation, and Degeneration 2020 Conference - Seite 2

Topline data from the trial showed that THR-687 was well-tolerated and safe with no dose-limiting toxicities. No serious adverse events were reported at any of the doses evaluated in the study.

The study also looked at efficacy including changes to the patient’s BCVA. Across all doses, a rapid onset of action in mean BCVA was observed from Day 1 with an increase of 3.1 letters, which further improved to 9.2 letters at Month 1. This activity was maintained with a mean BCVA improvement of 8.3 letters at Month 3 following a single injection of THR-687.

A clear dose response was seen with the greatest positive effect on BCVA with the highest dose of THR-687. For this highest dose, a mean BCVA Improvement of 11.2 letters was noted at Day 14, with a peak mean improvement of 12.5 letters at Month 3. Further, a peak mean CST (Central Subfield Thickness) decrease of 106 µm was observed at Day 14 with the highest dose of THR-687.

Patrik De Haes, M.D., CEO of Oxurion, said: “These encouraging findings from our Phase 1 study with THR-687, along with the very positive feedback we have received from the retinal community, highlight the significant potential of this novel integrin antagonist. We are on track to start a Phase 2 clinical study with THR-687 in treatment naïve DME patients in H2 2020.”

The presentation made by Arshad Khanani, M.D., M.A., at the Angiogenesis, Exudation, and Degeneration 2020 Conference can be found here.

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For further information please contact:

Oxurion NV Wouter Piepers, Global Head of Investor Relations & Corporate Communications Tel: [phone] [e-mail]

Citigate Dewe Rogerson David Dible/ Sylvie Berrebi/Frazer Hall Tel: [phone] [e-mail]

About Oxurion

Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care therapies, which are designed to better preserve vision in patients with diabetic eye disease, the leading cause of blindness in people of working age worldwide.

Oxurion’s clinical pipeline comprises:

-  THR-149, a plasma kallikrein inhibitor being developed as a potential new standard of care for DME patients who respond sub-optimally to anti-VEGF therapy.

THR-149 has shown positive topline Phase 1 results for the treatment of DME. The Company is currently preparing to conduct a Phase 2 clinical program, which is expected to start in H1 2020. THR-149 was developed in conjunction with Bicycle Therapeutics plc (NASDAQ:BCYC)