Oxurion NV – Expert Presentation of Positive Topline Data from a Phase 1 Study evaluating THR-687 for the treatment of DME,at Angiogenesis, Exudation, and Degeneration 2020 Conference

Oxurion NV – Expert Presentation of Positive Topline Data from a Phase 1 Study evaluating THR-687 for the treatment of DME,
at Angiogenesis, Exudation, and Degeneration 2020 Conference

Phase 2 study with THR-687 in treatment naïve DME patients to start in H2 2020

Leuven, Belgium, 9 February 2020 – Oxurion NV (Euronext Brussels: OXUR), a biopharmaceutical company developing next generation therapies designed to treat patients with diabetic eye disease, today announces that further positive topline data from a Phase 1 study with THR-687, a novel, potent, pan-RGD integrin antagonist for the treatment of Diabetic Macular Edema (DME) was presented by Arshad Khanani, M.D., M.A., Director of Clinical Research at Sierra Eye Associates, Reno, Nevada, US at the Angiogenesis, Exudation, and Degeneration 2020 conference on February 8, 2020, in Miami, US.

The Angiogenesis, Exudation, and Degeneration 2020 conference, organized by the world-renowned Bascom Palmer Eye Institute, featured an exceptional gathering of scientists, clinicians, and healthcare experts, all focused on understanding and treating neovascular and exudative diseases of the eye.

Arshad Khanani, M.D., M.A., Director of Clinical Research at Sierra Eye Associates, Reno, Nevada, US and one of the clinical investigators of the THR-687 Phase 1 study,  commenting on his presentation said, “I am delighted to have the opportunity to present these exciting THR-687 data at one of the most reputed global retina meetings. The topline Phase 1 data showed that THR-687 was safe and well tolerated at all of the dose levels tested. The study also demonstrated that THR-687 had a rapid positive effect on Best Corrected Visual Acuity (BCVA) that was durable for up to 3 months following just one single injection. I believe that these initial findings are very promising and further studies are needed to confirm the efficacy and safety of THR-687 in patients with DME.”

The Phase 1, open-label, multi-center (US), single dose escalation study evaluated the safety of a single intravitreal injection of 3 increasing doses of THR-687 (0.4 mg, 1.0 mg, 2.5 mg) for the treatment of DME (NCT 03666923). Patients recruited into the study had a history of response to prior anti-VEGF and/or corticosteroid treatment and remained responsive to treatment according to the investigator assessment.