Corbus Pharmaceuticals Announces Publication of Two Abstracts at EULAR 2020 E-Congress

• First abstract highlights pre-clinical data linking lenabasum’s mechanism of action to inhibiting inflammasome activation
• Second abstract outlines baseline characteristics of RESOLVE-1 patients in EU

Norwood, MA, May 22, 2020 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (“Corbus” or the “Company”), a clinical-stage drug development company pioneering transformative medicines that target the endocannabinoid system, today announced the publication of two abstracts at the European League Against Rheumatism (EULAR) 2020 E-Congress that will be taking place June 3-6, 2020.

Summarized below are the abstract titles that were selected for publication. The abstracts are published in the electronic "Abstract Book,” which is an official supplement to the "Annals of Rheumatic Diseases ARD.” The publications are also available in the Scientific Publications section of Corbus’ website.

Programme Number AB0152:

• Title: Lenabasum, a CB2 agonist, inhibits inflammasome activation
• Authors: Subba Chintalacharuvu, Corbus Pharmaceuticals, Inc.; Ping Zang, Corbus Pharmaceuticals, Inc.; Barbara White, M.D., Corbus Pharmaceuticals, Inc.; Sergei Atamas, M.D., Ph.D., Corbus Pharmaceuticals, Inc.
• Citation: Ann Rheum Dis, volume 79, supplement 1, year 2020, page 1372

Programme Number AB0568:

• Title: Baseline European Patient Demographics and Disease Characteristics in a Phase 3 Study of Safety and Efficacy of Lenabasum, a CB2 Agonist, in Diffuse Cutaneous Systemic Sclerosis
• Authors: Robert Spiera, M.D., Hospital for Special Surgery Main Hospital, New York; Nancy Dgetluck, Corbus Pharmaceuticals, Inc.; Bradley Bloom, M.D., Corbus Pharmaceuticals, Inc.; Barbara White, M.D., Corbus Pharmaceuticals, Inc.; Christopher Denton, M.D., Ph.D., FRCP, University College London
• Citation: Ann Rheum Dis, volume 79, supplement 1, year 2020, page 1576

About Lenabasum

Lenabasum is a rationally designed, oral, small molecule that selectively binds as an agonist to the cannabinoid receptor type 2 (CB2), resolves inflammation and limits fibrosis. CB2 is preferentially expressed on activated immune cells and on fibroblasts, muscle cells, and endothelial cells. In both animal and human studies conducted to date, lenabasum has induced the production of pro-resolving lipid mediators that activate endogenous pathways which resolve inflammation and speed bacterial clearance without immunosuppression. Data from animal models and human clinical studies suggest that lenabasum can reduce expression of genes and proteins involved in inflammation and fibrosis. Lenabasum has demonstrated promising activity in animal models of skin and lung inflammation and fibrosis in systemic sclerosis (SSc). Lenabasum is also active in animal models of lung infection and inflammation in cystic fibrosis and joint inflammation and scarring in rheumatoid arthritis.