Allogene Therapeutics Announces Oral Presentation of Phase 1 Data on ALLO-501/501A in Large B Cell Lymphoma at the International Conference on Malignant Lymphoma (ICML) Lugano

• Long-Term Follow Up Data from Phase 1 ALPHA/ALPHA2 Trials Demonstrates Potential of Allogeneic CD19 CAR T to Generate Durable Complete Responses Similar to Approved Autologous Therapies
• Presentation Recaps 12 Patients Treated with Phase 2 Dose Regimen and Includes Additional Data on All 33 CAR T Naïve Patients Treated with the Alloy Manufacturing Process
• Potentially Pivotal Phase 2 ALPHA2 Trials Ongoing in the US; Sites in Europe, Canada and Australia Expected to Enroll During 2023
  

SOUTH SAN FRANCISCO, Calif., June 09, 2023 (GLOBE NEWSWIRE) -- Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, today announced it will present data from the Phase 1 ALPHA/ALPHA2 trials of ALLO-501/501A in patients with relapsed/refractory (r/r) large B-cell lymphoma (LBCL) in an oral presentation at the International Conference on Malignant Lymphoma (ICML) on June 13–17, 2023 in Lugano, Switzerland. This presentation will feature additional data on the 33 CAR T naïve patients treated with the Alloy manufacturing process across different CAR T dosing and lymphodepletion regimens. Earlier in June, data from the 12 patients who received a single ALLO-501/A cell infusion following the lymphodepletion regimen being utilized in the ongoing potentially pivotal Phase 2 trials was presented at American Society of Clinical Oncology (ASCO) Annual Meeting.

The ALPHA/ALPHA2 Phase 1 trials were designed to assess the safety, tolerability, and preliminary efficacy at increasing dose levels of ALLO-501 and ALLO-501A, allogeneic CAR T cell product candidates that target CD19. In addition to exploring multiple cell doses and dosing schedules (consolidation), these studies evaluated various doses of ALLO-647, Allogene’s proprietary lymphodepleting antibody designed to prevent premature rejection of AlloCAR T cells. Allogene is currently enrolling the potentially pivotal Phase 2 ALPHA2 trial of ALLO-501A in LBCL and expects to complete enrollment in 1H2024. The Company expects to open trial sites in Europe, Canada and Australia during 2023.