Ironwood Pharmaceuticals to Present Four Abstracts at the ASPEN 2024 Nutrition Science & Practice Conference

Ironwood Pharmaceuticals, Inc. (Nasdaq: IRWD), a GI-focused healthcare company, announced today that the company will present findings from four studies evaluating apraglutide in adults with short bowel syndrome with intestinal failure (SBS-IF), a condition in which they are dependent on parenteral support, during the American Society for Parenteral and Enteral Nutrition (ASPEN) 2024 Nutrition Science & Practice Conference. ASPEN is being held from March 2-5, 2024, in Tampa, Florida.

SBS is a serious and chronic condition where there is diminished absorptive capacity for fluids and/or nutrients, typically resulting from extensive intestinal resection. Adult patients with SBS who are dependent on parenteral support (PS) to meet their nutritional and hydration needs, also referred to as SBS-IF, have significant quality of life impact and risk of severe complications such as infection. In these patients with SBS who are dependent on PS, the type of remnant bowel anatomy, such as colon-in-continuity or the presence of a jejunostomy or ileostomy, plays a critical role in how they respond to treatment.

The data being presented on apraglutide will include an oral presentation of fluid and energy absorption results at 4 weeks in SBS-IF with colon-in-continuity from the STARS Nutrition clinical trial, and poster presentations on apraglutide’s effect on reduction in PS needs and its safety profile in patients with SBS-IF with colon-in-continuity at one year, an epidemiological study of SBS-IF using real-world data, and an analysis of the pharmacokinetics of apraglutide in people with normal and impaired hepatic function.

“We are excited to share these findings on apraglutide with the international community of nutrition experts at ASPEN, a meeting which is singularly focused on critical nutrition support,” said Michael Shetzline, M.D., Ph.D., chief medical officer, senior vice president, and head of research and drug development at Ironwood Pharmaceuticals. “These findings continue to deepen our understanding of GLP-2 and the potential of apraglutide to help adult patients with SBS who are dependent on PS, including those with colon-in-continuity. Our hope is that if approved, apraglutide will have a positive impact on these patients.”