Ironwood Pharmaceuticals to Present Four Abstracts at the ASPEN 2024 Nutrition Science & Practice Conference - Seite 2

An estimated 18,000 adult patients in the U.S., Europe, and Japan suffer from SBS-IF, a rare and severe organ failure condition resulting from extensive intestinal resection, in which patients are dependent on PS to meet their nutritional and fluid requirements.

An overview of the presentations is below. Presentation details (abstracts, when available, can be accessed on the ASPEN 2024 meeting website at https://www.nutritioncare.org/abstracts/):

• The Novel Long-Acting Glp-2 Analog Apraglutide Improves Wet Weight Absorption in Patients with Short Bowel Syndrome with Intestinal Failure and Colon-In-Continuity
  • Oral presentation: March 3, 2:00 – 3:30 p.m. ET
• The Long-Acting GLP-2 Analog Apraglutide Reduces Parenteral Support Needs in Patients with Short Bowel Syndrome With Intestinal Failure and Colon in Continuity: 1-Year Results of a Multicenter, Open-Label, Phase 2 Trial
  • Poster presentation: March 3 and 4, 12:45 – 1:45 p.m. ET
• Epidemiology of Patients with Short Bowel Syndrome with Intestinal Failure (SBS-IF) in the US – Findings Using Real-World Data
  • Poster presentation: March 3 and 4, 12:45 – 1:45 p.m. ET
• Pharmacokinetics and Safety of Single-Dose Apraglutide in Individuals with Normal and Impaired Hepatic Function: A Phase 1, Open-Label Trial
  • Poster presentation: March 3 and 4, 12:45 – 1:45 p.m. ET

Ironwood is also sponsoring an Innovation Theater presentation entitled “Oral Nutrition in the Era of GLP-2: An Essential Factor in Maximizing Intestinal Adaptation for Patients With SBS-IF” on Sunday, March 3, from 12:45 to 1:30 p.m. ET. The presentation is chaired by Dr. Dejan Micic from the University of Chicago and will be joined by the faculty for an in-depth discussion on the importance of oral nutrition for patients with SBS-IF in the era of GLP-2 treatment.

About Short Bowel Syndrome (SBS)

SBS is a serious and chronic condition where there is diminished absorptive capacity for fluids and/or nutrients, sometimes requiring dependence on parenteral support to maintain health. Short bowel syndrome typically occurs because of extensive intestinal resection, and patients with SBS who are chronically dependent on parenteral support often experience significant quality of life impact and are at risk of severe complications such as infection. Patients with SBS with intestinal failure (SBS-IF) require PS to meet their nutritional and hydration needs, and the type of remnant bowel anatomy, such as colon-in-continuity or the presence of a jejunostomy or ileostomy, plays a critical role in how they respond to treatment.