Charles River Laboratories Showcases Technology-Driven Capabilities at AACR 2024

Charles River Laboratories International, Inc. (NYSE: CRL) announced today that its industry-leading team of oncology experts will attend the American Association for Cancer Research (AACR) Annual Meeting. Charles River will present technology-driven capabilities and highlight the latest advancements in immuno-oncology, in vitro assays, and more. The meeting is taking place from April 5-10, 2024, at the San Diego Convention Center in San Diego, California.

Charles River Launches New Tools & Services to Support Oncology Research
Charles River is showcasing an expanding portfolio of end-to-end cancer research tools and services, including:

• The Apollo Price Estimator, a new application that enables seamless generation of oncology study design, simplifies preclinical drug development by allowing clients to quickly generate price estimates.
• The Cancer Model Database, a tool that unlocks the ability to access different assays and comprehensive, well-characterized models for oncology drug development.
• Charles River is also expanding its cell sourcing offering to include same-day delivery of fresh leukopaks from its collection centers into the Cambridge and Greater Boston area as well as the San Diego biohub.

During the AACR Annual Meeting, the Charles River team will host a spotlight session and present over 20 scientific posters, including:

Spotlight Session: PDX: Predictive Tumor Models to Accelerate your Preclinical Research In Vivo, In Vitro and In Silico
Sunday, April 7, 1:30-2:30 p.m., Sails Pavilion Theater B

Charles River, Cypre Inc., and Aitia will come together to discuss the use of breakthrough technologies, such as PDX 3D tumor models and Digital Twins, in the process of identifying optimal drug candidates. The session will also cover the use of PDX-based in vitro 3D platforms in the context of the FDA Modernization Act and different in vivo screening formats. Featured speakers include:

• Julia Schueler, Therapeutic Area Lead, Charles River
• Isabelle Caffry, Senior Director of Strategy and Corporate Development, Aitia
• Kolin Hribar, CEO, Cypre

Poster #2714: Developing an mRNA Encoded Therapeutic Antibody Platform to Simplify Manufacturing and Reduce Time to Clinic
Monday, April 8, 1:30-5:00 p.m., Section 6

The production of therapeutic antibodies entails costly manufacturing processes, intricate purification methods, and extensive stability optimization, which contribute to elevated treatment expenses. Charles River’s poster will discuss the use of mRNA-based approaches to produce therapeutic antibodies in vivo, offering a promising strategy for solid tumor treatment, potentially reducing costs and improving biologic development.