Charles River Laboratories Showcases Technology-Driven Capabilities at AACR 2024 - Seite 2

Poster #4186: Development of an Orthotopic A549 Lung Carcinoma Model in CD34+ Humanized NCG Mice and Response to Treatment with Paclitaxel and Pembrolizumab
Tuesday, April 9, 9:00-12:30 p.m., Section 9

Translational in vivo models are critical to expediting the discovery of new treatments for lung cancer. In response to the growing demand for humanized models that can generate translatable outcomes, Charles River demonstrates the use of an orthotopic lung carcinoma model in humanized mice (HuCD34 NCG) to evaluate the activity of paclitaxel and pembrolizumab as single and combination agents.

To learn more about Charles River’s research tools and services portfolio, visit booth #1121 at the AACR Annual Meeting 2024. A full schedule of Charles River’s activities and reprints of each poster will be available online, and more content exploring topics discussed at the meeting will be shared on the Eureka Blog.

Approved Quotes

• “Our expert team of oncology researchers here at Charles River is committed to supporting clients across the R&D continuum, from basic research to IND and every stage in between. We look forward to showcasing innovative technology and digitally driven approaches to cancer research at the AACR Annual Meeting.” – Aidan Synnott, Corporate Vice President, Global Discovery Services, Charles River
• “In the dynamic landscape of oncology research, the pursuit of innovative solutions for predictive screening is imperative. Cypre’s proprietary 3D tumor microenvironment models platform expands Charles River’s oncology portfolio and offers our clients seamless, high-content analysis screening for their cancer immunotherapy and targeted therapy.” – Kolin Hribar, PhD, CEO & Founder, Cypre Inc.
• “Aitia and Charles River's joint effort to pioneer PDX Digital Twins stands at the forefront of a transformative shift in oncology research, aligning with the industry’s commitment to reduce reliance on traditional animal models. By integrating breakthrough technologies like PDX-based in vitro 3D platforms and Digital Twins, our collaborative efforts represent a significant leap towards advancing next-generation, in vivo oncology research across multiple cancer types.” – Isabelle Caffry, Senior Director of Strategy and Corporate Development, Aitia

About Charles River