Vincerx Pharma Presents Positive Preliminary Phase 1 Data for VIP236 and Updates on Pipeline Progress at the American Association for Cancer Research (AACR) Annual Meeting 2024

VIP236 demonstrated positive signs of clinical activity, including tumor reduction, and an improved safety profile in heavily pretreated patients with metastatic solid tumors

VIP943 pharmacokinetic (PK) data shows very little free payload in circulation, consistent with the favorable safety profile observed preclinically and clinically

In preclinical studies, Vincerx’s next-generation effector chemistry improves the efficacy of two approved antibody-drug conjugates (ADCs), highlighting VersAptx platform’s potential to advance cancer therapies

Management to host a virtual investor event today at 2:00 PM PDT / 5:00 PM EDT  

PALO ALTO, Calif., April 08, 2024 (GLOBE NEWSWIRE) -- Vincerx Pharma, Inc. (Nasdaq: VINC), a biopharmaceutical company aspiring to address the unmet medical needs of patients with cancer through paradigm-shifting therapeutics, today presented positive preliminary Phase 1 data for VIP236 and updates on pipeline progress at the American Association for Cancer Research (AACR) Annual Meeting 2024.

“The positive preliminary data we’ve reported for VIP236 and VIP943, coupled with preclinical findings leveraging our VersAptx platform to improve the efficacy of TRODELVY and ENHERTU, two marketed ADCs, underscore the power of our platform approach for hematologic malignancies and solid tumors,” said Ahmed Hamdy, M.D., Chief Executive Officer of Vincerx. “The early VIP236 data demonstrated positive clinical activity, including tumor reductions. This represents significant promise for patients who have exhausted standard anticancer therapy options with many different tumor types, including tumors not usually responsive to camptothecin-derived therapies. Dose escalation continues in the VIP236 and VIP943 first-in-human studies. As we advance into higher dose levels, we look forward to sharing more clinical data for VIP236 later this summer and for VIP943 on or around the 2024 European Hematology Association annual meeting.”

Raquel Izumi, Ph.D., President and Chief Operating Officer of Vincerx added, “The main objectives of a Phase 1 dose-escalation study are to assess safety and tolerability while establishing an optimal dose and schedule, so seeing dose-dependent clinical activity at this point in the development of VIP236 is exciting. We are still in dose escalation and are starting to see tumor reduction after only two doses. We expect to see responses deepen with more time on treatment and as we continue to escalate.”