BioXcel Therapeutics to Host Virtual Key Opinion Leader Event to Highlight BXCL501 as a Potential Treatment for Agitation and Opioid Withdrawal Symptoms - Seite 2

Opioid Withdrawal Symptoms

• Thomas R. Kosten, MD, is the JH Waggoner Chair and Professor of Psychiatry, Pharmacology, Immunology, Pathology, and Neuroscience of the Dan Duncan Institute for Clinical and Translational Research at Baylor College of Medicine. He has directed a national NIDA Medications Development Center since 1988, was previously the Research Director of the VA National Substance Use Disorders Quality Enhancement Research Initiative at the Michael E. DeBakey VA Medical Center and is the founder of the Division of Substance Abuse at Baylor College of Medicine and at Yale University School of Medicine.
  

Delirium Related Agitation

• E. Wesley Ely, MD, MPH, is a subspecialist in Pulmonary and Critical Care Medicine who conducts health services research as a Professor of Medicine in the Division of Allergy, Pulmonary, and Critical Care Medicine at Vanderbilt University Medical Center. He is a practicing intensivist with a focus on Geriatric ICU Care, as the Associate Director for Research for the VA Tennessee Valley Geriatric Research and Education Clinical Center. Dr. Ely is also the co-director of the Center for Critical Illness, Brain Dysfunction, and Survivorship, where his team developed the primary tool used to measure delirium clinically and in ICU-based trials.
  

A live webcast of the event will be accessible through the Investors section of the Company’s website at www.bioxceltherapeutics.com on February 19^th at 11:00 am ET. Following the event, the webcast will be archived on the Company’s website for at least 30 days.

About BXCL501

BXCL501 is an investigational, proprietary, orally dissolving thin film formulation of dexmedetomidine, a selective alpha-2a receptor agonist for the treatment of agitation and opioid withdrawal symptoms. BioXcel believes that BXCL501 directly targets a causal agitation mechanism, and the Company has observed anti-agitation results in multiple clinical studies across several neuropsychiatric disorders. BXCL501 has been granted Fast Track Designation by the U.S. Food and Drug Administration for the acute treatment of agitation in patients with schizophrenia, bipolar disorders, and dementia. BXCL501 has been studied in two Phase 3 trials (SERENITY I and II) for the acute treatment of schizophrenia related agitation and bipolar disorder related agitation, respectively, and in a Phase 1b/2 trial (TRANQUILITY) for the acute treatment of dementia related agitation. This product candidate is also currently being evaluated in a Phase 1b/2 study (RELEASE) for the treatment of opioid withdrawal symptoms, with plans to initiate a Phase 2 trial in hospitalized patients suffering from delirium related agitation within the next several months.