Alpha Cognition Receives Army Medical Research Grant for Study on Mild Traumatic Brain Injury (mTBI) from Blast Induced Functional Deficit and Brain Pathology

Alpha Cognition Inc. (CSE: ACOG) (OTCQB: ACOGF) (“Alpha Cognition” (ACI), or the “Company”), a biopharmaceutical company developing novel therapeutics for debilitating neurodegenerative disorders, is pleased to announce the that it has been awarded a $750,000 grant from the Army Medical Research and Material Command (AMRMC) for a pre-clinical study on the use of ALPHA-1062 Intranasal (IN) to reduce blast mTBI induced functional deficit and brain abnormalities.

The study grant will be issued by AMRMC and conducted in collaboration with the Seattle Institute for Biomedical and Clinical Research (SIBCR) and is endorsed by Department of Defense (DOD). The aim of the study is to evaluate the efficacy of ALPHA-1062IN in reducing the adverse effects of repetitive blast induced-mTBI in pre-clinical models.

A blast injury in military personnel occurs when a soldier is exposed to the powerful forces generated by explosions, such as those caused by bombs or improvised explosive devices (IEDs). Blast-related mTBI is a major concern for military personnel, particularly those who are deployed in combat zones. This type of injury can lead to long-term functional issues and brain abnormalities, which can have a significant impact on the quality of life of those affected.

“The body of evidence is growing to show that people who have suffered a TBI, even a mild TBI, are at greater risk of developing dementia in later life and are at risk for additional neurocognitive issues. An integral part of this research program will evaluate ALPHA-1062’s ability to reduce a toxic form of a brain protein [Tau] known to be increased in this military relevant TBI model,” commented Denis Kay, the study PI and Alpha Cognition’s Chief Scientific Officer. “Accumulation of toxic Tau in the brain is linked to dementia progression, and was previously shown to be decreased by ALPHA-1062 in a separate pre-clinical model of moderate TBI. We are excited to embark upon a trial to provide additional evidence for reduction of one of the neuropathological drivers of increased dementia risk.”

ALPHA-1062IN is a promising drug candidate that has shown potential for the treatment of mTBI. The drug has shown previous effectiveness in improving cognition and in improving movement and perceptive abilities in another pre-clinical study. This grant will further evaluate its effectiveness in reducing the adverse effects of blast-induced mTBI and potentially pave the way for clinical trials in the future.