Waters ZetaStar Instrument Boosts Speed and Sensitivity of Light Scattering Measurements for Biological Therapies

News Summary:

• New Zeta Star instrument for nanoparticle analysis from Wyatt Technology portfolio combines three light scattering techniques into a single device – cutting measurement time by up to 10x[i] over other methods.
• Measures biologic drug products at extremely low sample volumes to determine five critical parameters within one workflow, increasing efficiency, and also improves confidence in results.
• ZetaStar instrument supports workflows in gene therapy, vaccines, mRNA, proteins, and R&D laboratories to better optimize measurement of multiple species in complex mixtures and in fragile samples.

MILFORD, Mass., Sept. 20, 2023 /PRNewswire/ -- Waters Corporation (NYSE:WAT) introduces the DynaPro ZetaStar instrument from its Wyatt Technology portfolio for nanoparticle analysis. The new instrument simultaneously enables dynamic and static light scattering and dynamic and electrophoretic light scattering (DLS/SLS/ELS) measurements, all in one device. By combining multiple light scattering techniques and automatically assessing data quality and performing adaptive data capture, the ZetaStar instrument delivers both increased sensitivity and faster measurements to aid the precise development of complex biologics, using extremely low sample volumes.

"The integration of Waters and Wyatt has reached an exciting milestone with the introduction of the ZetaStar instrument as the first new product from our combined companies," said Dr. Udit Batra, President and CEO, Waters Corporation. "Developing lipid nanoparticle-based therapies that are effective and safe hinges on light scattering technologies, like those that are built in to the ZetaStar instrument. It uniquely combines three light scattering measurement techniques into a single device to provide more data points that can give biologics developers higher confidence in drug efficacy and stability."

A unique flow cell design allows the ZetaStar instrument to be configured with an autosampler, significantly increasing laboratory efficiency and productivity with dozens of unattended measurements that can be run for several hours or even overnight. The instrument's ability to measure simultaneous DLS and ELS along with the adaptive data collection functionality, improves the speed of traditional ELS measurements by up to 10xⁱ.